| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 21 | 21 | 8 | 11 | 3.27 | .273 | 1.10 | 7.0 | 3.0 | 8.6 | 137.2 | 106 | 50 | 50 | 12 | 45 | 131 | 1 | 0 | 0 | 1 | 15 | 4 | 0 | 3.30 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 20 | 20 | 3 | 13 | 4.92 | .316 | 1.36 | 9.9 | 2.4 | 8.7 | 133.2 | 147 | 76 | 73 | 16 | 35 | 129 | 3 | 0 | 0 | 0 | 10 | 3 | 3 | 3.48 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 20 | 20 | 9 | 9 | 4.45 | .315 | 1.34 | 9.4 | 2.8 | 4.3 | 143.2 | 149 | 72 | 71 | 16 | 44 | 68 | 5 | 0 | 0 | 0 | 11 | 5 | 4 | 4.53 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 19 | 19 | 5 | 12 | 5.78 | .344 | 1.57 | 10.2 | 3.9 | 4.9 | 120.0 | 136 | 80 | 77 | 12 | 52 | 65 | 4 | 0 | 0 | 0 | 7 | 1 | 4 | 4.54 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 43 | 0 | 1 | 1 | 2.18 | .237 | 0.91 | 4.2 | 4.1 | 8.5 | 53.2 | 25 | 14 | 13 | 4 | 24 | 50 | 0 | 6 | 2 | 0 | 0 | 1 | 0 | 3.51 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 25 | 0 | 2 | 1 | 6.45 | .391 | 1.93 | 11.9 | 5.7 | 11.0 | 22.1 | 29 | 18 | 16 | 2 | 14 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3.64 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 18 | 0 | 1 | 0 | 4.91 | .287 | 1.21 | 9.0 | 2.2 | 8.6 | 25.2 | 25 | 14 | 14 | 5 | 6 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.40 |