| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 14 | 14 | 12 | 2 | 2.55 | .234 | 0.91 | 5.2 | 3.0 | 8.5 | 109.1 | 63 | 31 | 31 | 11 | 36 | 103 | 3 | 0 | 0 | 0 | 10 | 1 | 0 | 3.44 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 13 | 13 | 9 | 1 | 2.38 | .251 | 0.97 | 6.0 | 2.8 | 6.9 | 90.2 | 60 | 26 | 24 | 7 | 28 | 69 | 1 | 0 | 0 | 1 | 10 | 3 | 4 | 3.51 |
| CL | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 93 | 25 | 0 | 2 | 1 | 0.34 | .175 | 0.64 | 1.7 | 4.2 | 10.7 | 26.2 | 5 | 1 | 1 | 1 | 12 | 31 | 0 | 16 | 0 | 0 | 0 | 0 | 1 | 2.50 |
| RP | Clippard, T.Clippard, Tyler >> | 28 | 2013 | R | 73 | 31 | 0 | 2 | 1 | 2.70 | .259 | 1.05 | 6.5 | 3.0 | 4.9 | 33.1 | 24 | 11 | 10 | 4 | 11 | 18 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 4.48 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 16 | 0 | 0 | 1 | 2.63 | .328 | 1.39 | 8.3 | 4.8 | 8.3 | 13.2 | 12 | 4 | 4 | 0 | 7 | 12 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.00 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 70 | 9 | 0 | 0 | 0 | 1.17 | .258 | 1.04 | 5.1 | 5.1 | 7.7 | 7.2 | 4 | 1 | 1 | 0 | 4 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 8 | 0 | 1 | 0 | 0.77 | .186 | 0.60 | 4.1 | 1.6 | 9.8 | 11.2 | 5 | 1 | 1 | 1 | 2 | 12 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.82 |