| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 37 | 37 | 18 | 15 | 3.18 | .267 | 1.08 | 6.8 | 2.9 | 7.8 | 266.0 | 201 | 95 | 94 | 21 | 87 | 232 | 12 | 0 | 0 | 3 | 26 | 3 | 8 | 3.30 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 35 | 35 | 14 | 14 | 4.46 | .293 | 1.23 | 8.3 | 2.8 | 5.4 | 238.0 | 219 | 120 | 118 | 24 | 73 | 142 | 9 | 0 | 0 | 1 | 18 | 4 | 6 | 4.09 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 34 | 34 | 15 | 15 | 3.80 | .282 | 1.16 | 8.3 | 2.2 | 5.4 | 253.1 | 233 | 116 | 107 | 21 | 62 | 152 | 10 | 0 | 0 | 1 | 20 | 3 | 6 | 3.65 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 31 | 31 | 13 | 9 | 4.26 | .314 | 1.36 | 8.5 | 3.8 | 4.0 | 202.2 | 190 | 99 | 96 | 23 | 85 | 90 | 3 | 0 | 0 | 1 | 15 | 3 | 5 | 4.90 |
| CL | Kimbrel, C.Kimbrel, Craig † >> | 24 | 2012 | R | 100 | 63 | 0 | 2 | 7 | 2.92 | .295 | 1.25 | 7.5 | 3.9 | 9.1 | 64.2 | 53 | 22 | 21 | 6 | 28 | 65 | 0 | 45 | 1 | 0 | 0 | 0 | 4 | 3.50 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 44 | 0 | 2 | 2 | 4.23 | .309 | 1.34 | 9.2 | 3.1 | 9.2 | 44.2 | 45 | 21 | 21 | 5 | 15 | 45 | 0 | 2 | 3 | 0 | 0 | 0 | 1 | 3.45 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 28 | 0 | 0 | 1 | 2.78 | .312 | 1.33 | 9.0 | 3.1 | 5.1 | 32.1 | 32 | 11 | 10 | 2 | 11 | 18 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.81 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 28 | 0 | 2 | 0 | 2.95 | .337 | 1.53 | 6.5 | 7.5 | 9.3 | 36.2 | 26 | 12 | 12 | 2 | 30 | 37 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 4.17 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 7 | 0 | 2 | 0 | 2.61 | .311 | 1.35 | 9.0 | 3.6 | 6.3 | 10.1 | 10 | 3 | 3 | 2 | 4 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.40 |