| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 20 | 20 | 10 | 8 | 3.21 | .272 | 1.10 | 7.5 | 2.4 | 8.6 | 148.2 | 124 | 59 | 53 | 10 | 39 | 142 | 5 | 0 | 0 | 1 | 11 | 4 | 1 | 2.83 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 19 | 19 | 10 | 5 | 3.40 | .281 | 1.14 | 7.7 | 2.6 | 5.5 | 143.0 | 122 | 57 | 54 | 14 | 41 | 87 | 4 | 0 | 0 | 2 | 11 | 5 | 5 | 4.02 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 19 | 19 | 9 | 8 | 3.92 | .285 | 1.19 | 7.2 | 3.5 | 7.0 | 142.1 | 114 | 63 | 62 | 16 | 55 | 111 | 4 | 0 | 0 | 0 | 12 | 1 | 2 | 4.08 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 18 | 18 | 5 | 8 | 5.02 | .280 | 1.17 | 8.4 | 2.2 | 5.6 | 100.1 | 93 | 57 | 56 | 21 | 24 | 62 | 0 | 0 | 0 | 0 | 7 | 0 | 1 | 5.21 |
| SP | Marichal, J.Marichal, Juan † >> | 29 | 1966 | R | 77 | 18 | 18 | 10 | 6 | 3.11 | .268 | 1.06 | 7.5 | 2.1 | 4.7 | 142.0 | 118 | 51 | 49 | 13 | 33 | 74 | 8 | 0 | 0 | 3 | 11 | 5 | 4 | 3.95 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 63 | 0 | 1 | 1 | 2.72 | .246 | 0.98 | 6.7 | 2.1 | 7.7 | 43.0 | 32 | 13 | 13 | 3 | 10 | 37 | 0 | 5 | 0 | 0 | 0 | 0 | 1 | 2.88 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 42 | 0 | 0 | 2 | 2.43 | .238 | 0.93 | 6.3 | 2.3 | 8.8 | 40.2 | 28 | 12 | 11 | 6 | 10 | 39 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.75 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 30 | 0 | 2 | 4 | 3.76 | .248 | 0.95 | 4.5 | 4.2 | 9.3 | 26.1 | 13 | 11 | 11 | 5 | 12 | 27 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 4.92 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 16 | 0 | 0 | 1 | 1.35 | .189 | 0.70 | 4.1 | 2.3 | 5.9 | 20.0 | 9 | 3 | 3 | 1 | 5 | 13 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.10 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 12 | 0 | 0 | 2 | 2.63 | .328 | 1.46 | 5.5 | 8.3 | 6.9 | 13.2 | 8 | 7 | 4 | 2 | 12 | 10 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 6.23 |