| SP | Leonard, D.Leonard, Dutch † >> | 22 | 1914 | L | 91 | 20 | 20 | 14 | 2 | 1.97 | .227 | 0.87 | 5.4 | 2.5 | 5.5 | 146.1 | 88 | 33 | 32 | 10 | 40 | 90 | 3 | 0 | 0 | 2 | 18 | 1 | 2 | 3.50 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 20 | 20 | 8 | 8 | 4.61 | .312 | 1.35 | 8.3 | 3.9 | 6.0 | 119.0 | 110 | 63 | 61 | 14 | 51 | 79 | 2 | 0 | 0 | 0 | 9 | 1 | 4 | 4.51 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 19 | 19 | 5 | 9 | 5.25 | .351 | 1.60 | 8.4 | 6.1 | 2.7 | 109.2 | 102 | 70 | 64 | 11 | 74 | 33 | 1 | 0 | 0 | 0 | 7 | 2 | 2 | 5.80 |
| CL | Street, H.Street, Huston † >> | 29 | 2012 | R | 96 | 44 | 0 | 2 | 0 | 3.64 | .288 | 1.19 | 6.4 | 4.3 | 8.4 | 42.0 | 30 | 20 | 17 | 5 | 20 | 39 | 0 | 24 | 3 | 0 | 0 | 1 | 0 | 4.19 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 44 | 0 | 1 | 2 | 2.80 | .289 | 1.20 | 7.6 | 3.2 | 5.6 | 45.0 | 38 | 14 | 14 | 4 | 16 | 28 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 4.04 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 79 | 30 | 0 | 4 | 2 | 2.83 | .333 | 1.40 | 8.0 | 4.8 | 10.6 | 28.2 | 25 | 9 | 9 | 4 | 15 | 33 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 4.43 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 24 | 0 | 0 | 0 | 4.60 | .338 | 1.53 | 7.4 | 6.5 | 9.3 | 29.1 | 24 | 15 | 15 | 2 | 21 | 30 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.00 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 9 | 0 | 1 | 1 | 3.72 | .333 | 1.45 | 9.9 | 3.3 | 8.1 | 19.1 | 21 | 8 | 8 | 1 | 7 | 17 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 3.16 |