| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 37 | 37 | 13 | 9 | 3.43 | .272 | 1.10 | 7.4 | 2.5 | 7.6 | 225.2 | 186 | 90 | 86 | 18 | 63 | 189 | 0 | 0 | 0 | 0 | 26 | 4 | 2 | 3.25 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 35 | 35 | 21 | 5 | 2.24 | .250 | 0.99 | 5.8 | 3.1 | 4.2 | 253.0 | 164 | 65 | 63 | 15 | 86 | 119 | 5 | 0 | 0 | 4 | 27 | 3 | 3 | 3.89 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 34 | 34 | 12 | 15 | 4.66 | .294 | 1.22 | 8.8 | 2.2 | 7.2 | 191.0 | 187 | 99 | 99 | 31 | 46 | 153 | 0 | 0 | 0 | 0 | 17 | 6 | 4 | 4.32 |
| SP | Fernandez, J.Fernandez, Jose # >> | 21 | 2013 | R | 76 | 36 | 34 | 18 | 8 | 2.94 | .267 | 1.09 | 6.8 | 3.0 | 7.7 | 229.1 | 173 | 77 | 75 | 16 | 76 | 197 | 2 | 0 | 0 | 0 | 25 | 2 | 5 | 3.21 |
| CL | Chapman, A.Chapman, Aroldis † >> | 26 | 2014 | L | 94 | 88 | 0 | 8 | 4 | 2.19 | .288 | 1.21 | 5.9 | 5.0 | 8.3 | 123.1 | 80 | 31 | 30 | 8 | 69 | 114 | 0 | 11 | 4 | 0 | 0 | 1 | 4 | 3.70 |
| RP | Eckersley, D.Eckersley, Dennis † >> | 36 | 1990 | R | 88 | 84 | 0 | 8 | 5 | 2.03 | .240 | 0.93 | 7.1 | 1.3 | 6.7 | 115.0 | 91 | 29 | 26 | 7 | 16 | 85 | 0 | 13 | 5 | 0 | 0 | 2 | 0 | 2.78 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 68 | 0 | 8 | 4 | 3.30 | .273 | 1.13 | 7.1 | 3.1 | 7.2 | 76.1 | 60 | 31 | 28 | 6 | 26 | 61 | 0 | 10 | 1 | 0 | 0 | 0 | 0 | 3.45 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 44 | 0 | 3 | 4 | 2.47 | .271 | 1.12 | 6.2 | 3.9 | 6.4 | 51.0 | 35 | 18 | 14 | 3 | 22 | 36 | 0 | 5 | 3 | 0 | 0 | 0 | 2 | 3.65 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 22 | 0 | 2 | 0 | 1.88 | .226 | 0.88 | 4.5 | 3.4 | 7.9 | 24.0 | 12 | 6 | 5 | 0 | 9 | 21 | 0 | 3 | 1 | 0 | 0 | 0 | 2 | 2.38 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 49 | 29 | 0 | 4 | 0 | 3.88 | .326 | 1.44 | 7.1 | 6.0 | 5.7 | 62.2 | 49 | 34 | 27 | 8 | 41 | 39 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 5.45 |