| SP | Scherzer, M.Scherzer, Max >> | 38 | 2022 | R | 92 | 32 | 32 | 13 | 10 | 3.86 | .282 | 1.16 | 7.8 | 2.7 | 10.4 | 212.1 | 183 | 92 | 91 | 31 | 64 | 244 | 2 | 0 | 0 | 2 | 19 | 3 | 1 | 3.55 |
| SP | Martinez, P.Martinez, Pedro † >> | 34 | 2005 | R | 87 | 31 | 31 | 13 | 7 | 3.66 | .275 | 1.10 | 7.2 | 2.7 | 7.7 | 216.1 | 172 | 91 | 88 | 25 | 65 | 184 | 4 | 0 | 0 | 3 | 19 | 9 | 1 | 3.83 |
| SP | Gooden, D.Gooden, Dwight # >> | 21 | 1985 | R | 88 | 31 | 31 | 13 | 10 | 3.83 | .285 | 1.17 | 7.8 | 2.8 | 8.5 | 218.1 | 188 | 94 | 93 | 21 | 67 | 205 | 6 | 0 | 0 | 2 | 19 | 6 | 2 | 3.38 |
| SP | Fernandez, S.Fernandez, Sid † >> | 23 | 1985 | L | 78 | 31 | 31 | 17 | 10 | 4.03 | .308 | 1.31 | 7.6 | 4.2 | 10.0 | 196.1 | 165 | 90 | 88 | 25 | 92 | 218 | 2 | 0 | 0 | 2 | 15 | 5 | 3 | 3.92 |
| RP | deGrom, J.deGrom, Jacob >> | 34 | 2022 | R | 97 | 87 | 0 | 12 | 3 | 3.50 | .280 | 1.15 | 7.7 | 2.7 | 10.7 | 138.2 | 118 | 58 | 54 | 17 | 41 | 164 | 0 | 3 | 4 | 0 | 0 | 3 | 0 | 3.18 |
| RP | Ottavino, A.Ottavino, Adam >> | 36 | 2022 | R | 64 | 59 | 0 | 4 | 1 | 3.77 | .295 | 1.21 | 8.5 | 2.4 | 10.4 | 59.2 | 56 | 25 | 25 | 8 | 16 | 68 | 0 | 2 | 3 | 0 | 0 | 3 | 4 | 3.42 |
| RP | Padilla, J.Padilla, Juan >> | 28 | 2005 | R | 58 | 39 | 0 | 3 | 4 | 4.72 | .366 | 1.72 | 10.0 | 5.6 | 6.4 | 55.1 | 61 | 30 | 29 | 9 | 34 | 39 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 5.62 |
| RP | Heilman, A.Heilman, Aaron >> | 27 | 2005 | R | 29 | 23 | 0 | 0 | 0 | 3.21 | .268 | 1.07 | 6.8 | 3.0 | 4.9 | 33.2 | 25 | 12 | 12 | 5 | 11 | 18 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.97 |
| RP | Orosco, J.Orosco, Jesse >> | 28 | 1985 | L | 19 | 23 | 0 | 2 | 1 | 4.25 | .353 | 1.56 | 8.0 | 6.0 | 7.8 | 36.0 | 32 | 17 | 17 | 3 | 24 | 31 | 0 | 0 | 0 | 0 | 0 | 3 | 3 | 4.61 |