| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 14 | 14 | 6 | 4 | 3.51 | .296 | 1.25 | 8.2 | 3.2 | 8.2 | 97.1 | 88 | 39 | 38 | 10 | 34 | 88 | 2 | 0 | 0 | 1 | 10 | 1 | 2 | 3.61 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 14 | 14 | 6 | 6 | 4.10 | .284 | 1.19 | 7.5 | 3.3 | 5.0 | 94.1 | 78 | 47 | 43 | 9 | 34 | 52 | 4 | 0 | 0 | 0 | 8 | 0 | 1 | 4.22 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 14 | 14 | 8 | 2 | 3.74 | .299 | 1.28 | 7.2 | 4.4 | 7.5 | 86.2 | 69 | 36 | 36 | 12 | 42 | 72 | 0 | 0 | 0 | 0 | 8 | 0 | 0 | 4.60 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 14 | 14 | 5 | 7 | 4.52 | .312 | 1.35 | 9.8 | 2.4 | 5.9 | 87.2 | 95 | 46 | 44 | 13 | 23 | 57 | 2 | 0 | 0 | 0 | 7 | 1 | 1 | 4.46 |
| SP | Waddell, R.Waddell, Rube # >> | 29 | 1905 | L | 67 | 15 | 14 | 8 | 6 | 3.95 | .288 | 1.20 | 8.2 | 2.7 | 6.0 | 98.0 | 89 | 46 | 43 | 8 | 29 | 65 | 1 | 0 | 1 | 0 | 9 | 1 | 1 | 3.65 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 41 | 0 | 2 | 1 | 4.27 | .280 | 1.17 | 7.2 | 3.3 | 6.8 | 46.1 | 37 | 22 | 22 | 6 | 17 | 35 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 4.28 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 24 | 0 | 0 | 0 | 1.14 | .240 | 0.95 | 3.8 | 4.9 | 9.0 | 31.2 | 13 | 4 | 4 | 1 | 17 | 31 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.06 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 23 | 0 | 3 | 2 | 5.32 | .268 | 1.10 | 7.4 | 2.7 | 7.8 | 23.2 | 19 | 14 | 14 | 4 | 7 | 20 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.43 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 17 | 0 | 0 | 0 | 2.38 | .277 | 1.10 | 7.8 | 2.5 | 6.1 | 22.2 | 19 | 6 | 6 | 3 | 6 | 15 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.36 |
| CL | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 29 | 0 | 0 | 4 | 2.70 | .318 | 1.40 | 8.4 | 4.2 | 8.4 | 30.0 | 28 | 9 | 9 | 2 | 14 | 28 | 0 | 19 | 0 | 0 | 0 | 0 | 0 | 3.40 |