| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 22 | 22 | 8 | 9 | 3.92 | .295 | 1.25 | 8.0 | 3.2 | 8.7 | 158.1 | 141 | 71 | 69 | 17 | 57 | 153 | 0 | 0 | 0 | 0 | 13 | 1 | 3 | 3.56 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 24 | 24 | 10 | 9 | 4.96 | .321 | 1.42 | 9.6 | 3.2 | 8.3 | 163.1 | 174 | 97 | 90 | 25 | 58 | 150 | 2 | 0 | 0 | 0 | 12 | 0 | 1 | 4.22 |
| SP | Horlen, J.Horlen, Joe # >> | 27 | 1964 | R | 78 | 24 | 24 | 9 | 9 | 4.64 | .302 | 1.29 | 8.6 | 3.1 | 4.9 | 172.2 | 164 | 90 | 89 | 24 | 59 | 93 | 4 | 0 | 0 | 1 | 11 | 1 | 0 | 4.78 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 23 | 23 | 6 | 9 | 5.86 | .333 | 1.47 | 10.2 | 3.1 | 4.2 | 156.2 | 177 | 108 | 102 | 22 | 54 | 72 | 3 | 0 | 0 | 0 | 7 | 4 | 5 | 5.03 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 24 | 23 | 8 | 9 | 3.86 | .303 | 1.30 | 8.9 | 2.9 | 4.4 | 144.2 | 142 | 71 | 62 | 14 | 46 | 71 | 1 | 1 | 0 | 1 | 14 | 1 | 2 | 4.26 |
| RP | Kimbrel, C.Kimbrel, Craig † >> | 24 | 2012 | R | 100 | 66 | 0 | 5 | 5 | 2.50 | .275 | 1.10 | 5.9 | 4.1 | 10.8 | 86.1 | 56 | 24 | 24 | 6 | 39 | 103 | 0 | 11 | 4 | 0 | 0 | 3 | 3 | 2.98 |
| RP | Rivera, M.Rivera, Mariano # >> | 39 | 2008 | R | 85 | 54 | 0 | 6 | 3 | 5.92 | .307 | 1.26 | 9.5 | 2.0 | 7.9 | 59.1 | 62 | 39 | 39 | 11 | 13 | 52 | 0 | 9 | 3 | 0 | 0 | 4 | 2 | 4.53 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 33 | 0 | 0 | 0 | 5.25 | .379 | 1.83 | 9.3 | 7.3 | 11.8 | 36.0 | 37 | 21 | 21 | 7 | 29 | 47 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 5.33 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 3 | 3 | 2 | 1 | 4.66 | .348 | 1.50 | 9.5 | 4.3 | 4.3 | 19.1 | 20 | 12 | 10 | 3 | 9 | 9 | 0 | 0 | 0 | 0 | 1 | 2 | 2 | 5.84 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 19 | 0 | 1 | 3 | 6.92 | .366 | 1.73 | 10.7 | 4.8 | 6.2 | 26.0 | 31 | 20 | 20 | 5 | 14 | 18 | 0 | 3 | 2 | 0 | 0 | 0 | 2 | 5.73 |