| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 25 | 25 | 9 | 10 | 3.31 | .270 | 1.10 | 8.3 | 1.6 | 10.0 | 157.2 | 145 | 60 | 58 | 19 | 28 | 174 | 1 | 0 | 0 | 0 | 18 | 2 | 0 | 2.93 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 23 | 23 | 6 | 8 | 5.87 | .348 | 1.58 | 10.7 | 3.6 | 5.4 | 125.2 | 149 | 91 | 82 | 25 | 50 | 75 | 1 | 0 | 0 | 0 | 8 | 2 | 3 | 5.65 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 23 | 23 | 7 | 12 | 5.62 | .345 | 1.53 | 9.5 | 4.3 | 7.2 | 117.0 | 123 | 76 | 73 | 17 | 56 | 94 | 1 | 0 | 0 | 1 | 10 | 6 | 1 | 4.87 |
| CL | Eckersley, D.Eckersley, Dennis † >> | 36 | 1990 | R | 87 | 51 | 0 | 5 | 3 | 3.79 | .293 | 1.21 | 8.7 | 2.2 | 8.4 | 57.0 | 55 | 26 | 24 | 7 | 14 | 53 | 0 | 23 | 2 | 0 | 0 | 2 | 0 | 3.58 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 62 | 0 | 2 | 0 | 3.68 | .283 | 1.18 | 7.1 | 3.5 | 7.4 | 66.0 | 52 | 32 | 27 | 6 | 26 | 54 | 0 | 3 | 4 | 0 | 0 | 0 | 0 | 3.73 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 61 | 0 | 4 | 3 | 6.42 | .355 | 1.64 | 9.1 | 5.8 | 9.3 | 61.2 | 62 | 45 | 44 | 10 | 39 | 63 | 0 | 0 | 1 | 0 | 0 | 1 | 3 | 5.03 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 67 | 0 | 1 | 1 | 3.86 | .293 | 1.18 | 6.9 | 3.9 | 8.9 | 67.2 | 51 | 32 | 29 | 12 | 29 | 66 | 0 | 1 | 1 | 0 | 0 | 4 | 0 | 4.84 |
| RP | Marshall, M.Marshall, Mike >> | 31 | 1974 | R | 2 | 53 | 0 | 4 | 4 | 6.43 | .400 | 1.99 | 13.2 | 4.7 | 5.1 | 77.0 | 113 | 63 | 55 | 13 | 40 | 44 | 0 | 2 | 1 | 0 | 0 | 1 | 5 | 5.65 |