| SP | Scherzer, M.Scherzer, Max # >> | 33 | 2017 | R | 95 | 30 | 30 | 11 | 13 | 4.18 | .281 | 1.15 | 7.5 | 2.9 | 8.1 | 181.0 | 151 | 93 | 84 | 20 | 58 | 163 | 2 | 0 | 0 | 1 | 17 | 3 | 5 | 3.65 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 84 | 29 | 29 | 4 | 15 | 5.51 | .311 | 1.32 | 9.5 | 2.3 | 4.0 | 188.0 | 199 | 117 | 115 | 27 | 49 | 84 | 0 | 0 | 0 | 0 | 11 | 6 | 3 | 4.85 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 29 | 29 | 6 | 16 | 5.09 | .331 | 1.44 | 9.0 | 3.9 | 5.7 | 196.1 | 197 | 123 | 111 | 23 | 85 | 125 | 1 | 0 | 0 | 0 | 11 | 9 | 13 | 4.69 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 28 | 28 | 8 | 13 | 5.62 | .334 | 1.48 | 10.1 | 3.3 | 5.0 | 174.2 | 195 | 110 | 109 | 23 | 63 | 96 | 4 | 0 | 0 | 0 | 11 | 5 | 4 | 4.79 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 28 | 28 | 11 | 15 | 5.28 | .333 | 1.48 | 10.6 | 2.7 | 8.7 | 177.1 | 209 | 110 | 104 | 25 | 53 | 172 | 4 | 0 | 0 | 0 | 13 | 4 | 7 | 3.86 |
| CL | Street, H.Street, Huston † # >> | 29 | 2012 | R | 96 | 48 | 0 | 6 | 6 | 5.51 | .306 | 1.30 | 8.3 | 3.6 | 7.0 | 50.2 | 46 | 35 | 31 | 7 | 20 | 39 | 0 | 25 | 3 | 0 | 0 | 1 | 1 | 4.52 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 63 | 0 | 5 | 4 | 3.61 | .295 | 1.24 | 6.4 | 4.9 | 9.5 | 72.1 | 51 | 31 | 29 | 6 | 39 | 76 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.64 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 63 | 42 | 0 | 1 | 1 | 6.09 | .376 | 1.74 | 10.0 | 5.7 | 8.8 | 44.1 | 49 | 30 | 30 | 9 | 28 | 43 | 0 | 1 | 2 | 0 | 0 | 3 | 1 | 5.82 |
| RP | Niedenfuer, T.Niedenfuer, Tom >> | 24 | 1983 | R | 62 | 30 | 0 | 1 | 3 | 5.12 | .291 | 1.20 | 7.3 | 3.8 | 4.6 | 31.2 | 25 | 18 | 18 | 6 | 13 | 16 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 5.84 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 60 | 26 | 0 | 1 | 0 | 5.00 | .336 | 1.41 | 8.3 | 4.3 | 7.0 | 27.0 | 25 | 17 | 15 | 6 | 13 | 21 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 6.11 |