| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 25 | 25 | 8 | 10 | 3.77 | .284 | 1.18 | 8.9 | 1.7 | 8.6 | 181.2 | 179 | 80 | 76 | 23 | 35 | 173 | 4 | 0 | 0 | 0 | 17 | 2 | 6 | 3.35 |
| SP | Nelson, R.Nelson, Roger # >> | 28 | 1972 | R | 85 | 24 | 24 | 6 | 9 | 5.15 | .336 | 1.48 | 10.2 | 3.0 | 6.5 | 124.0 | 141 | 75 | 71 | 19 | 42 | 90 | 0 | 0 | 0 | 0 | 5 | 5 | 3 | 4.68 |
| SP | Clemens, R.Clemens, Roger # >> | 24 | 1986 | R | 69 | 24 | 24 | 8 | 11 | 4.79 | .306 | 1.30 | 9.0 | 2.7 | 6.0 | 171.0 | 171 | 96 | 91 | 25 | 51 | 114 | 5 | 0 | 0 | 1 | 7 | 4 | 5 | 4.53 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 24 | 24 | 9 | 9 | 4.73 | .332 | 1.49 | 9.4 | 4.0 | 8.9 | 154.0 | 161 | 85 | 81 | 17 | 68 | 152 | 1 | 0 | 0 | 0 | 10 | 1 | 6 | 3.81 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 24 | 24 | 7 | 11 | 5.31 | .341 | 1.52 | 9.1 | 4.7 | 4.3 | 145.2 | 146 | 89 | 86 | 18 | 76 | 69 | 0 | 0 | 0 | 0 | 9 | 4 | 1 | 5.32 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 64 | 0 | 2 | 4 | 2.65 | .273 | 1.12 | 6.4 | 3.6 | 8.9 | 95.0 | 68 | 33 | 28 | 8 | 38 | 94 | 0 | 8 | 4 | 0 | 0 | 1 | 4 | 3.35 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 59 | 0 | 4 | 5 | 4.31 | .302 | 1.30 | 8.7 | 2.9 | 9.0 | 71.0 | 69 | 39 | 34 | 8 | 23 | 71 | 0 | 6 | 3 | 0 | 0 | 0 | 4 | 3.44 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 43 | 0 | 2 | 6 | 4.12 | .296 | 1.26 | 8.5 | 3.0 | 8.8 | 54.2 | 51 | 26 | 25 | 3 | 18 | 53 | 0 | 5 | 2 | 0 | 0 | 0 | 2 | 2.76 |
| RP | Fingers, R.Fingers, Rollie >> | 35 | 1981 | R | 54 | 28 | 0 | 2 | 2 | 5.12 | .328 | 1.42 | 9.8 | 3.2 | 7.2 | 45.2 | 49 | 30 | 26 | 9 | 16 | 36 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 5.20 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 9 | 0 | 4 | 0 | 3.46 | .291 | 1.23 | 8.3 | 2.8 | 9.7 | 13.0 | 12 | 7 | 5 | 1 | 4 | 14 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2.77 |