| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 20 | 20 | 7 | 10 | 4.05 | .284 | 1.18 | 8.1 | 2.6 | 9.6 | 126.2 | 113 | 58 | 57 | 17 | 36 | 134 | 1 | 0 | 0 | 0 | 12 | 2 | 0 | 3.53 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 43 | 15 | 15 | 11 | 1 | 3.38 | .316 | 1.35 | 8.0 | 4.2 | 7.7 | 96.0 | 85 | 39 | 36 | 8 | 45 | 82 | 1 | 0 | 0 | 1 | 11 | 3 | 10 | 3.88 |
| SP | Marichal, J.Marichal, Juan † >> | 29 | 1966 | R | 76 | 19 | 19 | 12 | 4 | 4.28 | .297 | 1.24 | 8.9 | 2.3 | 4.2 | 136.2 | 135 | 67 | 65 | 24 | 35 | 64 | 4 | 0 | 0 | 1 | 9 | 3 | 3 | 5.19 |
| CL | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 36 | 0 | 4 | 4 | 1.20 | .196 | 0.69 | 3.8 | 2.4 | 8.4 | 45.0 | 19 | 9 | 6 | 4 | 12 | 42 | 0 | 24 | 2 | 0 | 0 | 2 | 0 | 3.22 |
| SU | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 34 | 0 | 0 | 2 | 3.45 | .324 | 1.44 | 6.1 | 7.0 | 7.8 | 31.1 | 21 | 12 | 12 | 4 | 24 | 27 | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 5.26 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 29 | 0 | 1 | 1 | 2.66 | .282 | 1.18 | 4.5 | 6.3 | 10.8 | 20.1 | 10 | 6 | 6 | 0 | 14 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.70 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 68 | 23 | 0 | 1 | 1 | 3.79 | .337 | 1.53 | 9.0 | 4.7 | 6.2 | 19.0 | 19 | 8 | 8 | 1 | 10 | 13 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 3.89 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 35 | 0 | 2 | 1 | 2.79 | .293 | 1.21 | 6.8 | 4.0 | 8.7 | 29.0 | 22 | 9 | 9 | 1 | 13 | 28 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 2.97 |
| SP | Gibson, B.Gibson, Bob # >> | 33 | 1968 | R | 92 | 14 | 6 | 4 | 1 | 3.77 | .302 | 1.27 | 9.0 | 2.5 | 5.1 | 76.1 | 76 | 41 | 32 | 4 | 21 | 43 | 1 | 1 | 0 | 0 | 3 | 2 | 0 | 3.46 |