| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 27 | 27 | 13 | 9 | 4.07 | .293 | 1.18 | 8.8 | 1.9 | 8.5 | 203.2 | 199 | 96 | 92 | 22 | 42 | 191 | 3 | 0 | 0 | 1 | 15 | 12 | 3 | 3.33 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 27 | 27 | 9 | 12 | 4.38 | .310 | 1.30 | 9.0 | 2.7 | 9.2 | 183.0 | 184 | 105 | 89 | 28 | 54 | 188 | 2 | 0 | 0 | 0 | 14 | 9 | 4 | 3.97 |
| SP | Krause, H.Krause, Harry # >> | 21 | 1909 | L | 72 | 26 | 26 | 6 | 13 | 4.87 | .311 | 1.34 | 9.5 | 2.6 | 4.9 | 183.0 | 193 | 104 | 99 | 30 | 53 | 99 | 2 | 0 | 0 | 0 | 13 | 2 | 3 | 4.95 |
| RP | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 99 | 72 | 0 | 7 | 2 | 2.91 | .280 | 1.15 | 6.8 | 3.6 | 9.3 | 96.0 | 72 | 34 | 31 | 6 | 38 | 99 | 0 | 7 | 3 | 0 | 0 | 2 | 0 | 3.00 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 68 | 0 | 6 | 6 | 2.01 | .262 | 1.03 | 6.7 | 2.6 | 8.8 | 94.0 | 70 | 24 | 21 | 7 | 27 | 92 | 0 | 13 | 4 | 0 | 0 | 3 | 0 | 2.97 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 39 | 0 | 3 | 0 | 2.94 | .294 | 1.21 | 5.9 | 5.0 | 8.3 | 52.0 | 34 | 18 | 17 | 6 | 29 | 48 | 0 | 6 | 1 | 0 | 0 | 2 | 2 | 4.44 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 37 | 0 | 3 | 2 | 2.98 | .278 | 1.13 | 4.5 | 5.8 | 7.5 | 42.1 | 21 | 14 | 14 | 3 | 27 | 35 | 0 | 2 | 1 | 0 | 0 | 1 | 2 | 4.26 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 57 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 19 | 0 | 0 | 4 | 12.52 | .430 | 2.22 | 14.5 | 5.5 | 5.1 | 23.0 | 37 | 32 | 32 | 9 | 14 | 13 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 8.91 |