| SP | Martinez, P.Martinez, Pedro $$ >> | 29 | 2000 | R | 100 | 21 | 21 | 10 | 5 | 3.77 | .292 | 1.22 | 8.2 | 2.8 | 8.7 | 140.2 | 128 | 62 | 59 | 14 | 43 | 135 | 2 | 0 | 0 | 0 | 14 | 3 | 2 | 3.36 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 89 | 19 | 19 | 7 | 7 | 5.86 | .351 | 1.60 | 11.1 | 3.3 | 8.5 | 109.0 | 134 | 80 | 71 | 17 | 40 | 103 | 0 | 0 | 0 | 0 | 10 | 3 | 3 | 4.32 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 99 | 37 | 0 | 3 | 3 | 2.45 | .328 | 1.44 | 9.5 | 3.6 | 7.2 | 40.1 | 42 | 11 | 11 | 2 | 16 | 32 | 0 | 21 | 2 | 0 | 0 | 1 | 1 | 3.33 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 26 | 0 | 0 | 2 | 3.51 | .280 | 1.13 | 6.8 | 3.6 | 10.4 | 25.2 | 19 | 10 | 10 | 5 | 10 | 29 | 0 | 1 | 3 | 0 | 0 | 1 | 0 | 4.60 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 77 | 31 | 0 | 1 | 2 | 6.51 | .341 | 1.52 | 10.7 | 3.3 | 8.0 | 27.2 | 32 | 20 | 20 | 9 | 10 | 24 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 6.78 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 21 | 0 | 0 | 1 | 2.57 | .267 | 1.10 | 6.9 | 3.0 | 4.7 | 21.0 | 16 | 6 | 6 | 2 | 7 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.19 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 80 | 17 | 0 | 0 | 0 | 2.55 | .338 | 1.53 | 10.6 | 3.7 | 9.0 | 17.2 | 20 | 7 | 5 | 0 | 7 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.24 |