| SP | Martinez, P.Martinez, Pedro $ >> | 29 | 2000 | R | 100 | 27 | 27 | 11 | 10 | 4.58 | .292 | 1.23 | 9.0 | 2.1 | 8.8 | 171.0 | 171 | 98 | 87 | 19 | 39 | 168 | 2 | 0 | 0 | 1 | 15 | 2 | 5 | 3.20 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 26 | 26 | 6 | 8 | 4.98 | .308 | 1.33 | 9.5 | 2.5 | 6.1 | 132.0 | 139 | 77 | 73 | 18 | 36 | 90 | 0 | 0 | 0 | 0 | 9 | 1 | 2 | 4.25 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 25 | 25 | 6 | 14 | 5.79 | .332 | 1.49 | 10.7 | 2.8 | 4.9 | 158.2 | 187 | 104 | 102 | 25 | 49 | 86 | 3 | 0 | 0 | 0 | 8 | 1 | 5 | 4.92 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 98 | 48 | 0 | 2 | 5 | 3.73 | .290 | 1.16 | 7.2 | 3.4 | 8.1 | 50.2 | 40 | 23 | 21 | 4 | 19 | 45 | 0 | 27 | 4 | 0 | 0 | 3 | 1 | 3.56 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 38 | 0 | 0 | 2 | 4.42 | .305 | 1.29 | 7.6 | 4.3 | 8.1 | 38.2 | 32 | 19 | 19 | 9 | 18 | 34 | 0 | 2 | 6 | 0 | 0 | 1 | 0 | 5.79 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 37 | 0 | 4 | 1 | 1.61 | .263 | 1.05 | 6.5 | 3.1 | 9.0 | 50.1 | 36 | 11 | 9 | 3 | 17 | 50 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 2.86 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 76 | 27 | 0 | 1 | 1 | 3.78 | .286 | 1.20 | 7.6 | 3.3 | 9.0 | 33.1 | 28 | 19 | 14 | 1 | 12 | 33 | 0 | 1 | 0 | 0 | 0 | 0 | 4 | 2.48 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 25 | 0 | 2 | 1 | 4.94 | .326 | 1.42 | 9.9 | 2.9 | 9.0 | 31.0 | 34 | 18 | 17 | 5 | 10 | 31 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.16 |