| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 93 | 21 | 21 | 11 | 5 | 3.31 | .248 | 0.98 | 6.1 | 2.7 | 8.0 | 149.1 | 101 | 57 | 55 | 12 | 45 | 132 | 2 | 0 | 0 | 1 | 14 | 2 | 2 | 3.22 |
| SP | Mathewson, C.Mathewson, Christy $$ >> | 28 | 1908 | R | 82 | 19 | 19 | 10 | 7 | 3.41 | .279 | 1.12 | 8.3 | 1.8 | 5.1 | 129.1 | 119 | 51 | 49 | 12 | 26 | 73 | 2 | 0 | 0 | 1 | 13 | 5 | 5 | 3.80 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 40 | 0 | 3 | 4 | 3.32 | .266 | 1.08 | 6.7 | 3.1 | 6.5 | 43.1 | 32 | 16 | 16 | 9 | 15 | 31 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 5.33 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 28 | 0 | 2 | 2 | 2.59 | .305 | 1.32 | 5.6 | 6.4 | 12.0 | 24.1 | 15 | 8 | 7 | 0 | 17 | 32 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 2.46 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 48 | 17 | 0 | 0 | 1 | 7.71 | .385 | 1.88 | 14.5 | 3.0 | 9.0 | 18.2 | 29 | 19 | 16 | 5 | 6 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.61 |
| CL | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 96 | 34 | 0 | 1 | 1 | 3.45 | .288 | 1.18 | 7.3 | 3.5 | 8.1 | 31.1 | 25 | 12 | 12 | 7 | 12 | 28 | 0 | 28 | 3 | 0 | 0 | 1 | 0 | 5.39 |