| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 93 | 27 | 27 | 15 | 9 | 3.03 | .273 | 1.12 | 7.5 | 2.6 | 8.3 | 199.1 | 165 | 73 | 67 | 12 | 58 | 184 | 7 | 0 | 0 | 2 | 20 | 1 | 1 | 2.82 |
| SP | Mathewson, C.Mathewson, Christy $ >> | 28 | 1908 | R | 83 | 24 | 24 | 13 | 2 | 2.77 | .263 | 1.06 | 7.8 | 1.8 | 5.6 | 181.2 | 156 | 60 | 56 | 12 | 36 | 113 | 1 | 0 | 0 | 0 | 16 | 2 | 4 | 3.24 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 68 | 0 | 3 | 2 | 3.07 | .220 | 0.84 | 6.5 | 1.1 | 6.4 | 55.2 | 40 | 19 | 19 | 5 | 7 | 39 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 3.15 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 45 | 0 | 1 | 2 | 1.04 | .217 | 0.83 | 4.8 | 2.7 | 9.8 | 43.1 | 23 | 5 | 5 | 4 | 13 | 47 | 0 | 6 | 1 | 0 | 0 | 0 | 0 | 2.93 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 34 | 0 | 3 | 5 | 3.16 | .319 | 1.40 | 7.6 | 5.4 | 11.9 | 25.2 | 21 | 14 | 9 | 4 | 15 | 33 | 0 | 5 | 1 | 0 | 0 | 0 | 1 | 4.24 |
| CL | Chapman, A.Chapman, Aroldis # >> | 37 | 2025 | L | 96 | 50 | 0 | 2 | 2 | 6.75 | .385 | 1.81 | 11.2 | 5.3 | 7.4 | 29.1 | 36 | 22 | 22 | 3 | 17 | 24 | 0 | 5 | 6 | 0 | 0 | 2 | 2 | 4.66 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 19 | 5 | 4 | 4 | 5.38 | .340 | 1.52 | 9.3 | 4.4 | 4.7 | 82.0 | 85 | 54 | 49 | 9 | 40 | 43 | 0 | 0 | 0 | 0 | 2 | 2 | 1 | 4.91 |