| SP | Alexander, P.Alexander, Pete # $$ >> | 28 | 1915 | R | 88 | 31 | 31 | 14 | 11 | 4.43 | .319 | 1.38 | 9.4 | 3.1 | 4.4 | 227.2 | 238 | 122 | 112 | 35 | 77 | 112 | 11 | 0 | 0 | 3 | 16 | 5 | 2 | 5.10 |
| SP | Snell, B.Snell, Blake # >> | 25 | 2018 | L | 81 | 29 | 29 | 12 | 11 | 4.46 | .299 | 1.25 | 7.2 | 4.1 | 8.6 | 167.2 | 134 | 87 | 83 | 17 | 76 | 159 | 1 | 0 | 0 | 0 | 13 | 5 | 11 | 3.87 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 30 | 30 | 8 | 14 | 5.86 | .345 | 1.53 | 10.5 | 3.4 | 7.9 | 190.1 | 221 | 129 | 124 | 47 | 71 | 167 | 2 | 0 | 0 | 0 | 11 | 9 | 8 | 5.72 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 29 | 29 | 9 | 14 | 5.93 | .334 | 1.49 | 10.1 | 3.3 | 4.8 | 179.0 | 201 | 126 | 118 | 31 | 66 | 96 | 6 | 0 | 0 | 2 | 11 | 2 | 14 | 5.32 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 74 | 0 | 8 | 5 | 4.98 | .324 | 1.41 | 9.1 | 3.6 | 9.0 | 99.1 | 100 | 58 | 55 | 16 | 40 | 99 | 0 | 8 | 8 | 0 | 0 | 3 | 0 | 4.40 |
| RP | Papelbon, J.Papelbon, Jonathan † >> | 27 | 2007 | R | 92 | 63 | 0 | 7 | 3 | 4.07 | .309 | 1.32 | 7.4 | 4.6 | 8.9 | 79.2 | 65 | 36 | 36 | 12 | 40 | 78 | 0 | 7 | 3 | 0 | 0 | 2 | 0 | 4.59 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 25 | 0 | 1 | 4 | 5.40 | .409 | 2.00 | 10.8 | 7.2 | 9.4 | 25.0 | 30 | 17 | 15 | 3 | 20 | 26 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 5.12 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 2 | 1 | 1 | 0 | 2.08 | .316 | 1.38 | 11.3 | 2.3 | 4.5 | 8.2 | 10 | 4 | 2 | 0 | 2 | 4 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2.75 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 28 | 0 | 0 | 0 | 6.75 | .333 | 1.50 | 10.0 | 3.5 | 8.4 | 28.0 | 31 | 22 | 21 | 4 | 11 | 26 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.18 |