| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 32 | 32 | 11 | 13 | 5.31 | .329 | 1.43 | 9.9 | 3.0 | 8.7 | 171.1 | 188 | 114 | 101 | 24 | 57 | 165 | 3 | 0 | 0 | 0 | 14 | 7 | 0 | 4.02 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 89 | 31 | 31 | 10 | 11 | 6.18 | .333 | 1.47 | 9.8 | 3.5 | 8.1 | 164.2 | 178 | 117 | 113 | 40 | 64 | 147 | 1 | 0 | 0 | 0 | 12 | 5 | 0 | 5.64 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 32 | 31 | 14 | 6 | 4.39 | .303 | 1.26 | 8.5 | 2.8 | 9.2 | 196.2 | 185 | 103 | 96 | 23 | 62 | 200 | 2 | 0 | 0 | 1 | 16 | 9 | 6 | 3.57 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 31 | 31 | 17 | 11 | 4.39 | .325 | 1.43 | 9.7 | 3.2 | 5.3 | 188.2 | 202 | 92 | 92 | 31 | 67 | 110 | 4 | 0 | 0 | 1 | 15 | 4 | 0 | 5.11 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 32 | 29 | 9 | 9 | 4.56 | .337 | 1.47 | 9.4 | 3.9 | 5.7 | 179.2 | 187 | 96 | 91 | 17 | 78 | 114 | 2 | 0 | 0 | 0 | 13 | 9 | 5 | 4.42 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 82 | 0 | 5 | 9 | 4.27 | .322 | 1.42 | 8.5 | 4.4 | 9.1 | 92.2 | 87 | 45 | 44 | 13 | 45 | 93 | 0 | 30 | 5 | 0 | 0 | 0 | 0 | 4.28 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 74 | 0 | 6 | 3 | 5.52 | .372 | 1.77 | 10.0 | 6.0 | 9.0 | 75.0 | 83 | 46 | 46 | 17 | 50 | 75 | 0 | 2 | 4 | 0 | 0 | 0 | 2 | 5.95 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 66 | 0 | 3 | 0 | 5.56 | .354 | 1.63 | 10.6 | 4.1 | 8.2 | 81.0 | 95 | 52 | 50 | 9 | 37 | 74 | 0 | 2 | 0 | 0 | 0 | 1 | 11 | 4.02 |