| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 18 | 16 | 4 | 8 | 4.23 | .303 | 1.28 | 8.1 | 3.5 | 5.9 | 112.2 | 101 | 56 | 53 | 11 | 43 | 73 | 3 | 0 | 0 | 0 | 9 | 3 | 3 | 4.21 |
| SP | Kershaw, C.Kershaw, Clayton # >> | 28 | 2016 | L | 99 | 32 | 32 | 12 | 11 | 3.67 | .255 | 1.02 | 7.9 | 1.3 | 8.0 | 252.1 | 222 | 103 | 103 | 31 | 35 | 223 | 10 | 0 | 0 | 1 | 17 | 2 | 10 | 3.27 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 28 | 28 | 7 | 12 | 4.97 | .328 | 1.43 | 8.7 | 4.3 | 3.4 | 184.2 | 177 | 108 | 102 | 22 | 87 | 69 | 1 | 0 | 0 | 0 | 12 | 7 | 3 | 5.34 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 93 | 69 | 0 | 1 | 1 | 3.32 | .256 | 1.00 | 5.7 | 3.3 | 11.1 | 65.0 | 41 | 24 | 24 | 6 | 24 | 80 | 0 | 2 | 3 | 0 | 0 | 2 | 4 | 2.94 |
| CL | Saito, T.Saito, Takashi † >> | 37 | 2007 | R | 91 | 62 | 0 | 10 | 9 | 4.96 | .320 | 1.38 | 9.6 | 2.9 | 8.1 | 78.0 | 83 | 48 | 43 | 12 | 25 | 70 | 0 | 25 | 5 | 0 | 0 | 2 | 0 | 4.24 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 57 | 0 | 5 | 3 | 3.38 | .319 | 1.36 | 8.1 | 4.3 | 8.6 | 42.2 | 38 | 20 | 16 | 5 | 20 | 40 | 0 | 3 | 0 | 0 | 0 | 2 | 4 | 4.21 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 59 | 0 | 5 | 0 | 4.21 | .279 | 1.09 | 6.8 | 3.2 | 6.2 | 57.2 | 43 | 28 | 27 | 7 | 20 | 39 | 0 | 4 | 4 | 0 | 0 | 4 | 1 | 4.49 |