| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 26 | 26 | 8 | 12 | 4.17 | .292 | 1.21 | 8.0 | 2.9 | 9.2 | 157.2 | 140 | 75 | 73 | 23 | 51 | 160 | 2 | 0 | 0 | 0 | 17 | 4 | 0 | 3.92 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 27 | 27 | 7 | 16 | 5.22 | .329 | 1.44 | 10.4 | 2.6 | 8.2 | 150.0 | 173 | 91 | 87 | 21 | 43 | 137 | 1 | 0 | 0 | 0 | 10 | 5 | 3 | 3.95 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 27 | 27 | 10 | 9 | 4.60 | .312 | 1.32 | 9.1 | 2.9 | 5.4 | 162.1 | 163 | 86 | 83 | 20 | 52 | 98 | 5 | 0 | 0 | 1 | 14 | 6 | 2 | 4.47 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 27 | 27 | 7 | 12 | 7.35 | .380 | 1.81 | 12.4 | 4.0 | 4.6 | 138.1 | 190 | 116 | 113 | 19 | 61 | 71 | 0 | 0 | 0 | 0 | 7 | 3 | 2 | 5.15 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 27 | 26 | 8 | 14 | 5.36 | .335 | 1.49 | 9.4 | 4.1 | 5.0 | 149.1 | 155 | 97 | 89 | 22 | 68 | 82 | 3 | 0 | 0 | 1 | 11 | 3 | 0 | 5.25 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 79 | 0 | 4 | 1 | 3.55 | .263 | 1.06 | 5.4 | 4.2 | 9.5 | 99.0 | 59 | 42 | 39 | 5 | 46 | 105 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2.96 |
| CL | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 94 | 61 | 0 | 6 | 5 | 1.51 | .226 | 0.88 | 4.0 | 4.0 | 9.2 | 77.2 | 34 | 13 | 13 | 8 | 34 | 79 | 0 | 24 | 0 | 0 | 0 | 0 | 0 | 3.62 |
| SU | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 62 | 0 | 4 | 2 | 2.61 | .270 | 1.08 | 6.3 | 3.5 | 6.4 | 79.1 | 55 | 23 | 23 | 7 | 31 | 56 | 0 | 3 | 3 | 0 | 0 | 2 | 0 | 3.99 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 64 | 0 | 1 | 1 | 3.70 | .309 | 1.31 | 8.6 | 3.2 | 9.2 | 75.1 | 72 | 31 | 31 | 18 | 27 | 77 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 5.23 |