| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 18 | 18 | 6 | 9 | 4.31 | .293 | 1.24 | 7.9 | 3.2 | 9.1 | 119.0 | 105 | 65 | 57 | 16 | 42 | 120 | 3 | 0 | 0 | 1 | 10 | 1 | 1 | 3.82 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 84 | 17 | 17 | 4 | 9 | 4.91 | .310 | 1.30 | 9.6 | 2.1 | 4.5 | 117.1 | 125 | 67 | 64 | 9 | 27 | 59 | 2 | 0 | 0 | 1 | 6 | 6 | 7 | 3.84 |
| SP | Hendrix, C.Hendrix, Claude † # >> | 25 | 1914 | R | 69 | 17 | 17 | 12 | 3 | 3.69 | .286 | 1.18 | 8.3 | 2.4 | 4.8 | 134.0 | 123 | 57 | 55 | 14 | 35 | 72 | 7 | 0 | 0 | 0 | 10 | 3 | 4 | 4.13 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 16 | 16 | 5 | 5 | 4.26 | .330 | 1.48 | 9.0 | 4.4 | 3.1 | 101.1 | 101 | 52 | 48 | 11 | 49 | 35 | 0 | 0 | 0 | 0 | 9 | 0 | 3 | 5.18 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 53 | 0 | 2 | 1 | 2.19 | .265 | 1.05 | 6.8 | 2.7 | 9.0 | 37.0 | 28 | 10 | 9 | 2 | 11 | 37 | 0 | 5 | 1 | 0 | 0 | 1 | 1 | 2.68 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 50 | 0 | 2 | 7 | 6.97 | .338 | 1.51 | 10.8 | 2.9 | 6.1 | 50.1 | 60 | 39 | 39 | 9 | 16 | 34 | 0 | 6 | 5 | 0 | 0 | 1 | 0 | 5.00 |
| RP | Dotel, O.Dotel, Octavio † >> | 29 | 2002 | R | 69 | 34 | 0 | 5 | 2 | 2.50 | .279 | 1.16 | 6.0 | 4.6 | 9.0 | 39.2 | 26 | 11 | 11 | 4 | 20 | 39 | 0 | 5 | 1 | 0 | 0 | 0 | 1 | 3.87 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 59 | 10 | 0 | 0 | 2 | 6.17 | .340 | 1.54 | 8.2 | 6.5 | 8.2 | 11.2 | 10 | 10 | 8 | 3 | 8 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.91 |