| SP | Martinez, P.Martinez, Pedro † # >> | 29 | 2000 | R | 100 | 37 | 37 | 21 | 13 | 3.38 | .262 | 1.05 | 7.3 | 2.1 | 8.4 | 287.2 | 234 | 111 | 108 | 20 | 68 | 269 | 15 | 0 | 0 | 5 | 23 | 4 | 5 | 2.78 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 35 | 35 | 17 | 14 | 3.71 | .295 | 1.23 | 8.6 | 2.5 | 5.6 | 276.2 | 264 | 121 | 114 | 24 | 76 | 173 | 9 | 0 | 0 | 1 | 18 | 7 | 3 | 3.78 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 34 | 34 | 19 | 7 | 4.02 | .306 | 1.29 | 8.1 | 3.5 | 8.3 | 239.1 | 215 | 116 | 107 | 30 | 94 | 221 | 3 | 0 | 0 | 1 | 20 | 8 | 6 | 4.06 |
| SP | Horlen, J.Horlen, Joe # >> | 27 | 1964 | R | 78 | 33 | 33 | 10 | 18 | 5.64 | .339 | 1.52 | 10.3 | 3.4 | 4.7 | 209.0 | 240 | 136 | 131 | 31 | 78 | 110 | 1 | 0 | 0 | 0 | 12 | 4 | 4 | 5.05 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 31 | 31 | 11 | 14 | 5.15 | .327 | 1.45 | 9.2 | 3.9 | 5.7 | 222.0 | 226 | 147 | 127 | 29 | 95 | 140 | 4 | 0 | 0 | 1 | 12 | 3 | 4 | 4.76 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 87 | 0 | 4 | 3 | 3.55 | .290 | 1.20 | 7.0 | 3.9 | 9.3 | 101.1 | 78 | 42 | 40 | 5 | 44 | 104 | 0 | 14 | 3 | 0 | 0 | 2 | 8 | 2.95 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 39 | 0 | 4 | 1 | 2.30 | .212 | 0.81 | 5.6 | 1.7 | 6.5 | 47.0 | 29 | 12 | 12 | 3 | 9 | 34 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 2.96 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 28 | 0 | 2 | 0 | 4.06 | .326 | 1.45 | 9.9 | 3.2 | 10.2 | 31.0 | 34 | 14 | 14 | 5 | 11 | 35 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 3.90 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 60 | 26 | 0 | 0 | 0 | 3.07 | .273 | 1.13 | 7.1 | 3.1 | 9.9 | 29.1 | 23 | 10 | 10 | 4 | 10 | 32 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.62 |