| SP | Young, C.Young, Chris $ >> | 28 | 2007 | R | 82 | 32 | 32 | 15 | 8 | 3.62 | .315 | 1.36 | 7.3 | 5.0 | 7.4 | 176.1 | 142 | 73 | 71 | 24 | 97 | 145 | 0 | 0 | 0 | 0 | 16 | 4 | 2 | 4.85 |
| SP | Schilling, C.Schilling, Curt † >> | 36 | 2002 | R | 93 | 33 | 33 | 18 | 6 | 3.38 | .272 | 1.11 | 8.3 | 1.6 | 9.2 | 234.1 | 217 | 88 | 88 | 28 | 42 | 240 | 8 | 0 | 0 | 2 | 21 | 4 | 5 | 3.09 |
| SP | Maddux, G.Maddux, Greg # >> | 34 | 2000 | R | 57 | 30 | 30 | 11 | 6 | 6.41 | .345 | 1.55 | 10.9 | 3.1 | 6.7 | 150.1 | 181 | 110 | 107 | 30 | 52 | 111 | 0 | 0 | 0 | 0 | 8 | 5 | 5 | 5.26 |
| CL | Broxton, J.Broxton, Jonathan † >> | 25 | 2009 | R | 80 | 61 | 0 | 4 | 3 | 2.73 | .250 | 0.95 | 5.6 | 2.9 | 11.3 | 56.0 | 35 | 18 | 17 | 5 | 18 | 70 | 0 | 33 | 5 | 0 | 0 | 3 | 1 | 2.79 |
| RP | Percival, T.Percival, Troy >> | 38 | 2007 | R | 84 | 48 | 0 | 3 | 1 | 3.94 | .315 | 1.36 | 8.7 | 3.7 | 6.2 | 61.2 | 59 | 30 | 27 | 12 | 25 | 42 | 0 | 1 | 0 | 0 | 0 | 1 | 3 | 5.46 |
| RP | Williamson, S.Williamson, Scott >> | 26 | 2002 | R | 50 | 42 | 0 | 4 | 2 | 3.33 | .339 | 1.52 | 8.1 | 5.8 | 9.2 | 48.2 | 43 | 20 | 18 | 5 | 31 | 49 | 0 | 1 | 0 | 0 | 0 | 1 | 7 | 4.31 |
| RP | Seanez, R.Seanez, Rudy >> | 37 | 2005 | R | 20 | 29 | 0 | 2 | 1 | 2.23 | .292 | 1.18 | 6.5 | 4.3 | 9.5 | 36.1 | 26 | 10 | 9 | 3 | 17 | 38 | 0 | 0 | 2 | 0 | 0 | 2 | 4 | 3.56 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 64 | 34 | 0 | 2 | 2 | 3.35 | .310 | 1.35 | 8.0 | 4.2 | 8.2 | 43.0 | 38 | 16 | 16 | 6 | 20 | 39 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 4.40 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 55 | 0 | 5 | 0 | 3.36 | .289 | 1.15 | 7.8 | 2.6 | 11.0 | 69.2 | 60 | 29 | 26 | 9 | 20 | 84 | 0 | 3 | 2 | 0 | 0 | 5 | 4 | 3.35 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 70 | 59 | 0 | 4 | 0 | 2.42 | .312 | 1.29 | 8.4 | 3.3 | 5.7 | 74.1 | 69 | 23 | 20 | 8 | 27 | 47 | 0 | 1 | 2 | 0 | 0 | 5 | 1 | 4.43 |
| RP | Masset, N.Masset, Nick >> | 27 | 2009 | R | 44 | 28 | 0 | 2 | 1 | 4.06 | .363 | 1.71 | 9.0 | 6.4 | 5.5 | 31.0 | 31 | 14 | 14 | 5 | 22 | 19 | 0 | 1 | 2 | 0 | 0 | 0 | 3 | 6.00 |