| SP | Johnson, R.Johnson, Randy $ >> | 38 | 2001 | L | 97 | 37 | 37 | 15 | 15 | 4.20 | .306 | 1.31 | 8.2 | 3.6 | 9.2 | 244.0 | 222 | 118 | 114 | 31 | 97 | 249 | 3 | 0 | 0 | 0 | 19 | 3 | 4 | 3.84 |
| SP | Loaiza, E.Loaiza, Esteban # >> | 32 | 2003 | R | 59 | 36 | 35 | 13 | 11 | 4.97 | .321 | 1.40 | 9.7 | 3.0 | 7.8 | 195.2 | 210 | 114 | 108 | 37 | 64 | 169 | 2 | 0 | 0 | 1 | 16 | 3 | 3 | 4.76 |
| RP | Williamson, S.Williamson, Scott >> | 26 | 2002 | R | 50 | 51 | 0 | 3 | 1 | 3.96 | .315 | 1.35 | 7.0 | 5.3 | 10.0 | 63.2 | 49 | 29 | 28 | 12 | 37 | 70 | 0 | 0 | 1 | 0 | 0 | 2 | 4 | 5.11 |
| RP | Papelbon, J.Papelbon, Jonathan † $ >> | 26 | 2006 | R | 93 | 72 | 0 | 1 | 5 | 3.71 | .292 | 1.19 | 7.7 | 3.1 | 9.4 | 70.1 | 60 | 33 | 29 | 8 | 24 | 73 | 0 | 45 | 7 | 0 | 0 | 3 | 1 | 3.56 |
| RP | Percival, T.Percival, Troy >> | 38 | 2007 | R | 84 | 61 | 0 | 4 | 2 | 4.39 | .330 | 1.41 | 8.0 | 4.8 | 6.4 | 69.2 | 61 | 34 | 34 | 14 | 37 | 49 | 0 | 1 | 0 | 0 | 0 | 5 | 5 | 6.04 |
| RP | White, G.White, Gabe $ >> | 29 | 2000 | L | 56 | 48 | 0 | 4 | 0 | 3.56 | .286 | 1.17 | 8.1 | 2.5 | 7.1 | 68.1 | 61 | 27 | 27 | 6 | 19 | 54 | 0 | 2 | 1 | 0 | 0 | 2 | 1 | 3.49 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 68 | 74 | 0 | 3 | 3 | 6.24 | .350 | 1.57 | 8.3 | 5.9 | 11.4 | 83.2 | 77 | 60 | 58 | 7 | 54 | 105 | 0 | 1 | 2 | 0 | 0 | 4 | 4 | 3.66 |
| SP | Alvarez, W.Alvarez, Wilson # >> | 33 | 2003 | L | 74 | 23 | 19 | 7 | 5 | 4.34 | .311 | 1.34 | 8.7 | 3.5 | 6.6 | 105.2 | 101 | 51 | 51 | 11 | 41 | 77 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 4.10 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 86 | 32 | 31 | 12 | 11 | 4.90 | .330 | 1.46 | 11.0 | 2.1 | 6.4 | 191.0 | 234 | 114 | 104 | 31 | 45 | 135 | 4 | 0 | 0 | 0 | 13 | 3 | 4 | 4.45 |