| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 33 | 33 | 12 | 14 | 4.17 | .300 | 1.26 | 8.3 | 3.1 | 9.0 | 211.1 | 195 | 109 | 98 | 35 | 72 | 210 | 2 | 0 | 0 | 1 | 19 | 5 | 6 | 4.26 |
| SP | Weaver, J.Weaver, Jered >> | 24 | 2006 | R | 83 | 32 | 32 | 7 | 14 | 5.39 | .339 | 1.50 | 9.3 | 4.3 | 6.7 | 177.0 | 182 | 110 | 106 | 27 | 84 | 132 | 0 | 0 | 0 | 0 | 13 | 6 | 1 | 5.02 |
| SP | Williams, W.Williams, Woody >> | 36 | 2002 | R | 78 | 32 | 32 | 7 | 12 | 5.54 | .340 | 1.50 | 11.0 | 2.6 | 6.9 | 172.1 | 210 | 107 | 106 | 34 | 49 | 131 | 0 | 0 | 0 | 0 | 15 | 7 | 2 | 5.02 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 69 | 32 | 32 | 12 | 13 | 5.29 | .358 | 1.65 | 10.1 | 4.8 | 6.8 | 192.1 | 216 | 119 | 113 | 30 | 102 | 145 | 0 | 0 | 0 | 0 | 16 | 4 | 4 | 5.18 |
| SP | Wakefield, T.Wakefield, Tim >> | 36 | 2002 | R | 84 | 31 | 31 | 10 | 8 | 3.92 | .307 | 1.27 | 8.1 | 3.4 | 7.0 | 147.0 | 132 | 69 | 64 | 13 | 55 | 115 | 0 | 0 | 0 | 0 | 4 | 8 | 4 | 3.87 |
| CL | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 96 | 70 | 0 | 6 | 9 | 2.60 | .265 | 1.07 | 7.6 | 2.1 | 8.7 | 69.1 | 58 | 20 | 20 | 9 | 16 | 67 | 0 | 39 | 2 | 0 | 0 | 1 | 1 | 3.49 |
| SU | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 84 | 67 | 0 | 3 | 2 | 3.65 | .321 | 1.39 | 8.0 | 4.6 | 11.5 | 69.0 | 61 | 28 | 28 | 7 | 35 | 88 | 0 | 3 | 7 | 0 | 0 | 2 | 7 | 3.38 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 76 | 67 | 0 | 5 | 1 | 4.55 | .307 | 1.31 | 9.7 | 2.1 | 8.7 | 63.1 | 68 | 32 | 32 | 10 | 15 | 61 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.89 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 67 | 45 | 0 | 6 | 3 | 3.62 | .266 | 1.07 | 7.7 | 2.0 | 9.4 | 49.2 | 42 | 20 | 20 | 5 | 11 | 51 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 2.98 |
| RP | Marte, D.Marte, Damaso # >> | 28 | 2003 | L | 54 | 93 | 0 | 3 | 1 | 4.05 | .270 | 1.11 | 5.5 | 4.6 | 12.1 | 66.2 | 40 | 30 | 30 | 13 | 34 | 89 | 0 | 1 | 4 | 0 | 0 | 0 | 2 | 4.41 |
| SP | Shields, J.Shields, James >> | 26 | 2007 | R | 52 | 36 | 0 | 3 | 1 | 6.03 | .368 | 1.71 | 12.1 | 3.3 | 7.7 | 112.0 | 151 | 82 | 75 | 25 | 41 | 96 | 0 | 0 | 0 | 0 | 0 | 4 | 2 | 5.39 |