| SP | Martinez, P.Martinez, Pedro $ >> | 29 | 2000 | R | 100 | 36 | 36 | 18 | 10 | 4.15 | .299 | 1.25 | 8.4 | 2.9 | 10.7 | 251.1 | 234 | 128 | 116 | 28 | 80 | 299 | 6 | 0 | 0 | 4 | 21 | 7 | 2 | 3.11 |
| SP | Carpenter, C.Carpenter, Chris >> | 34 | 2009 | R | 80 | 36 | 36 | 13 | 12 | 5.04 | .332 | 1.46 | 9.9 | 3.2 | 6.2 | 230.1 | 253 | 132 | 129 | 30 | 83 | 158 | 4 | 0 | 0 | 1 | 15 | 7 | 5 | 4.50 |
| SP | Hamels, C.Hamels, Cole >> | 25 | 2008 | L | 72 | 31 | 31 | 10 | 10 | 6.29 | .363 | 1.69 | 11.7 | 3.6 | 8.2 | 164.2 | 213 | 118 | 115 | 40 | 65 | 149 | 0 | 0 | 0 | 0 | 13 | 4 | 0 | 5.62 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 65 | 33 | 31 | 10 | 16 | 7.42 | .375 | 1.73 | 11.5 | 4.1 | 5.8 | 163.2 | 209 | 140 | 135 | 47 | 74 | 105 | 1 | 1 | 0 | 0 | 8 | 12 | 3 | 7.04 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 71 | 80 | 0 | 3 | 3 | 3.75 | .291 | 1.23 | 7.9 | 3.2 | 11.1 | 98.1 | 86 | 48 | 41 | 12 | 35 | 121 | 0 | 1 | 0 | 0 | 0 | 0 | 3 | 3.19 |
| SU | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 70 | 68 | 0 | 4 | 6 | 3.84 | .303 | 1.29 | 8.5 | 3.1 | 6.6 | 75.0 | 71 | 32 | 32 | 10 | 26 | 55 | 0 | 1 | 5 | 0 | 0 | 1 | 0 | 4.35 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 79 | 61 | 0 | 4 | 1 | 3.55 | .285 | 1.18 | 5.9 | 4.7 | 10.7 | 76.0 | 50 | 30 | 30 | 9 | 40 | 90 | 0 | 1 | 0 | 0 | 0 | 1 | 4 | 3.79 |