| SP | Hernandez, F.Hernandez, Felix † $ >> | 19 | 2005 | R | 96 | 20 | 20 | 9 | 9 | 2.91 | .278 | 1.14 | 7.9 | 2.4 | 7.5 | 145.1 | 128 | 54 | 47 | 17 | 38 | 121 | 3 | 0 | 0 | 1 | 15 | 2 | 6 | 3.68 |
| SP | Buehrle, M.Buehrle, Mark † >> | 22 | 2001 | L | 68 | 19 | 19 | 12 | 6 | 4.21 | .324 | 1.40 | 9.4 | 3.3 | 7.1 | 126.0 | 131 | 65 | 59 | 14 | 46 | 99 | 2 | 0 | 0 | 0 | 13 | 4 | 2 | 4.06 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 67 | 19 | 19 | 6 | 5 | 5.25 | .340 | 1.55 | 10.9 | 3.1 | 5.8 | 123.1 | 149 | 77 | 72 | 23 | 42 | 79 | 1 | 0 | 0 | 0 | 7 | 0 | 1 | 5.17 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 88 | 53 | 0 | 2 | 2 | 3.77 | .278 | 1.09 | 6.7 | 3.2 | 7.5 | 59.2 | 44 | 28 | 25 | 8 | 21 | 49 | 0 | 0 | 2 | 0 | 0 | 4 | 2 | 4.37 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 79 | 24 | 0 | 1 | 2 | 2.66 | .253 | 1.01 | 4.7 | 4.7 | 11.3 | 23.2 | 12 | 7 | 7 | 2 | 12 | 29 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.17 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 69 | 11 | 0 | 1 | 1 | 2.87 | .242 | 0.89 | 5.4 | 3.0 | 10.2 | 15.2 | 9 | 5 | 5 | 0 | 5 | 17 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1.93 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 53 | 54 | 0 | 0 | 1 | 1.59 | .237 | 0.91 | 6.5 | 1.8 | 8.1 | 39.2 | 28 | 8 | 7 | 3 | 8 | 35 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.90 |