| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 6 | 6 | 2 | 2 | 5.08 | .361 | 1.69 | 11.5 | 4.1 | 12.0 | 33.2 | 42 | 22 | 19 | 8 | 15 | 44 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 4.85 |
| SP | Wakefield, T.Wakefield, Tim >> | 36 | 2002 | R | 84 | 6 | 5 | 0 | 1 | 3.98 | .322 | 1.43 | 9.0 | 4.1 | 7.2 | 20.1 | 20 | 9 | 9 | 3 | 9 | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 4.70 |
| SP | Bedard, E.Bedard, Erik >> | 28 | 2007 | L | 81 | 5 | 5 | 2 | 2 | 7.11 | .361 | 1.66 | 10.8 | 4.3 | 8.6 | 25.1 | 30 | 22 | 20 | 8 | 12 | 24 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 6.80 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 5 | 5 | 0 | 2 | 12.12 | .430 | 2.27 | 19.1 | 1.7 | 10.1 | 16.1 | 34 | 22 | 22 | 4 | 3 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.56 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 88 | 15 | 0 | 2 | 0 | 5.89 | .295 | 1.20 | 5.0 | 6.0 | 6.5 | 18.1 | 10 | 12 | 12 | 2 | 12 | 13 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 5.17 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 84 | 15 | 0 | 2 | 1 | 3.29 | .406 | 2.05 | 12.5 | 6.9 | 12.5 | 13.2 | 18 | 8 | 5 | 0 | 10 | 18 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 2.54 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 63 | 18 | 0 | 1 | 0 | 4.11 | .303 | 1.30 | 7.8 | 4.2 | 7.8 | 15.1 | 13 | 7 | 7 | 2 | 7 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.40 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 53 | 16 | 0 | 0 | 2 | 5.94 | .324 | 1.44 | 10.7 | 2.8 | 7.3 | 16.2 | 19 | 11 | 11 | 3 | 5 | 13 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.75 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 94 | 13 | 0 | 2 | 0 | 3.07 | .313 | 1.36 | 9.6 | 3.2 | 10.3 | 14.2 | 15 | 5 | 5 | 2 | 5 | 16 | 0 | 4 | 1 | 0 | 0 | 0 | 2 | 3.64 |