| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 34 | 34 | 14 | 19 | 4.23 | .305 | 1.31 | 8.8 | 3.0 | 7.9 | 246.2 | 241 | 125 | 116 | 34 | 82 | 217 | 8 | 0 | 0 | 0 | 17 | 2 | 2 | 4.06 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 83 | 32 | 32 | 12 | 12 | 5.19 | .318 | 1.38 | 10.2 | 2.2 | 7.7 | 213.1 | 242 | 127 | 123 | 42 | 52 | 183 | 0 | 0 | 0 | 0 | 12 | 4 | 4 | 4.63 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 32 | 32 | 6 | 18 | 6.97 | .357 | 1.63 | 11.3 | 3.4 | 5.8 | 187.1 | 235 | 148 | 145 | 39 | 70 | 120 | 6 | 0 | 0 | 1 | 7 | 7 | 5 | 5.66 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 31 | 31 | 8 | 15 | 5.81 | .348 | 1.58 | 10.4 | 3.9 | 5.7 | 190.2 | 220 | 128 | 123 | 32 | 82 | 120 | 3 | 0 | 0 | 2 | 9 | 3 | 10 | 5.27 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 56 | 0 | 5 | 4 | 3.55 | .285 | 1.18 | 7.6 | 3.0 | 8.6 | 66.0 | 56 | 28 | 26 | 9 | 22 | 63 | 0 | 20 | 5 | 0 | 0 | 1 | 0 | 3.91 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 83 | 0 | 4 | 2 | 5.58 | .344 | 1.57 | 9.1 | 5.1 | 9.5 | 98.1 | 99 | 62 | 61 | 16 | 55 | 103 | 0 | 1 | 3 | 0 | 0 | 1 | 11 | 4.73 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 76 | 0 | 7 | 1 | 3.45 | .273 | 1.12 | 6.8 | 3.2 | 9.4 | 86.0 | 65 | 33 | 33 | 10 | 31 | 90 | 0 | 2 | 1 | 0 | 0 | 1 | 3 | 3.53 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 75 | 58 | 0 | 0 | 5 | 6.49 | .320 | 1.36 | 9.3 | 3.0 | 9.9 | 61.0 | 63 | 46 | 44 | 13 | 20 | 67 | 0 | 1 | 2 | 0 | 0 | 3 | 5 | 4.70 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 85 | 17 | 0 | 3 | 1 | 3.48 | .301 | 1.26 | 8.7 | 2.6 | 10.7 | 31.0 | 30 | 14 | 12 | 5 | 9 | 37 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.68 |