| SP | deGrom, J.deGrom, Jacob # >> | 33 | 2021 | R | 100 | 22 | 22 | 9 | 6 | 3.57 | .274 | 1.12 | 7.8 | 2.3 | 9.9 | 146.1 | 126 | 65 | 58 | 19 | 38 | 160 | 1 | 0 | 0 | 1 | 13 | 2 | 0 | 3.32 |
| SP | Brown, M.Brown, Mordecai † >> | 32 | 1908 | R | 84 | 21 | 21 | 14 | 5 | 4.37 | .307 | 1.32 | 9.0 | 2.9 | 4.4 | 162.2 | 162 | 84 | 79 | 18 | 52 | 79 | 8 | 0 | 0 | 2 | 10 | 2 | 7 | 4.47 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 20 | 20 | 7 | 10 | 4.26 | .321 | 1.35 | 9.4 | 2.9 | 4.4 | 154.1 | 160 | 73 | 73 | 21 | 49 | 76 | 7 | 0 | 0 | 0 | 10 | 10 | 5 | 4.94 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 20 | 20 | 5 | 9 | 5.13 | .338 | 1.48 | 9.7 | 3.7 | 4.3 | 133.1 | 143 | 78 | 76 | 15 | 54 | 63 | 2 | 0 | 0 | 1 | 10 | 7 | 6 | 4.89 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 48 | 0 | 3 | 3 | 2.21 | .249 | 0.97 | 5.6 | 3.2 | 7.4 | 85.2 | 53 | 21 | 21 | 3 | 30 | 70 | 0 | 7 | 3 | 0 | 0 | 2 | 0 | 2.94 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 79 | 38 | 0 | 4 | 3 | 4.10 | .328 | 1.42 | 9.4 | 3.5 | 8.6 | 41.2 | 43 | 19 | 19 | 7 | 16 | 39 | 0 | 3 | 1 | 0 | 0 | 2 | 1 | 4.63 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 60 | 19 | 0 | 2 | 1 | 2.67 | .221 | 0.81 | 5.7 | 1.7 | 8.7 | 27.0 | 17 | 9 | 8 | 3 | 5 | 26 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.19 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 4 | 0 | 0 | 0 | 8.31 | .409 | 2.08 | 11.3 | 9.0 | 6.8 | 4.1 | 5 | 4 | 4 | 1 | 4 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 7.75 |