| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 16 | 16 | 7 | 7 | 4.47 | .325 | 1.44 | 9.7 | 3.4 | 5.6 | 102.2 | 110 | 56 | 51 | 14 | 38 | 63 | 0 | 0 | 0 | 0 | 9 | 0 | 1 | 4.67 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 15 | 15 | 5 | 7 | 4.52 | .307 | 1.28 | 6.8 | 4.8 | 8.9 | 73.2 | 55 | 37 | 37 | 12 | 39 | 72 | 0 | 0 | 0 | 0 | 6 | 4 | 2 | 4.93 |
| SP | Pfiester, J.Pfiester, Jack # >> | 28 | 1906 | L | 74 | 15 | 15 | 5 | 4 | 5.51 | .336 | 1.49 | 9.6 | 3.8 | 4.7 | 85.0 | 91 | 54 | 52 | 11 | 36 | 44 | 0 | 0 | 0 | 0 | 5 | 2 | 2 | 4.99 |
| SP | Cicotte, E.Cicotte, Eddie # >> | 33 | 1917 | R | 73 | 15 | 15 | 8 | 2 | 2.98 | .241 | 0.94 | 6.4 | 2.1 | 3.4 | 93.2 | 66 | 31 | 31 | 9 | 22 | 35 | 2 | 0 | 0 | 2 | 11 | 1 | 1 | 4.25 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 80 | 26 | 0 | 1 | 1 | 3.21 | .322 | 1.37 | 7.9 | 4.6 | 8.7 | 33.2 | 29 | 13 | 12 | 5 | 17 | 32 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 4.76 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 68 | 22 | 0 | 6 | 1 | 3.27 | .291 | 1.23 | 7.0 | 4.2 | 5.9 | 41.1 | 32 | 15 | 15 | 5 | 19 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.66 |
| SU | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 31 | 0 | 0 | 1 | 1.67 | .215 | 0.82 | 5.4 | 2.2 | 8.8 | 37.2 | 22 | 7 | 7 | 1 | 9 | 36 | 0 | 1 | 3 | 0 | 0 | 0 | 1 | 2.14 |
| SP | McGinnity, J.McGinnity, Joe >> | 33 | 1904 | R | 50 | 7 | 0 | 2 | 2 | 8.49 | .352 | 1.63 | 13.9 | 1.6 | 8.2 | 11.2 | 17 | 11 | 11 | 2 | 2 | 10 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4.09 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 21 | 0 | 1 | 0 | 0.28 | .159 | 0.57 | 2.6 | 2.6 | 9.3 | 31.2 | 9 | 1 | 1 | 1 | 9 | 32 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.23 |