| SP | Brown, M.Brown, Mordecai † # >> | 32 | 1908 | R | 85 | 27 | 27 | 13 | 8 | 3.03 | .267 | 1.08 | 7.4 | 2.3 | 4.6 | 196.1 | 162 | 73 | 66 | 12 | 50 | 100 | 8 | 0 | 0 | 4 | 20 | 3 | 2 | 3.59 |
| SP | Pfiester, J.Pfiester, Jack # >> | 28 | 1906 | L | 74 | 27 | 27 | 8 | 13 | 5.02 | .313 | 1.36 | 8.7 | 3.5 | 3.7 | 170.1 | 164 | 101 | 95 | 14 | 67 | 69 | 6 | 0 | 0 | 0 | 11 | 2 | 4 | 4.48 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 25 | 25 | 8 | 9 | 4.42 | .311 | 1.31 | 9.0 | 2.8 | 7.9 | 158.2 | 158 | 83 | 78 | 27 | 50 | 139 | 3 | 0 | 0 | 1 | 11 | 7 | 0 | 4.54 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 68 | 0 | 5 | 3 | 2.13 | .272 | 1.10 | 7.1 | 2.8 | 8.5 | 93.0 | 73 | 23 | 22 | 8 | 29 | 88 | 0 | 4 | 2 | 0 | 0 | 2 | 0 | 3.23 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 62 | 0 | 6 | 3 | 2.06 | .280 | 1.13 | 7.0 | 3.1 | 8.1 | 83.0 | 65 | 20 | 19 | 7 | 29 | 75 | 0 | 6 | 2 | 0 | 0 | 3 | 1 | 3.45 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 54 | 0 | 5 | 1 | 2.74 | .255 | 1.03 | 6.4 | 2.9 | 5.0 | 69.0 | 49 | 21 | 21 | 3 | 22 | 38 | 0 | 10 | 0 | 0 | 0 | 0 | 0 | 3.42 |
| RP | Fingers, R.Fingers, Rollie >> | 35 | 1981 | R | 54 | 30 | 0 | 1 | 2 | 2.62 | .251 | 0.94 | 5.3 | 3.3 | 5.9 | 44.2 | 26 | 13 | 13 | 1 | 16 | 29 | 0 | 2 | 1 | 0 | 0 | 3 | 0 | 3.27 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 1 | 0 | 0 | 0 | 13.50 | .455 | 2.50 | 9.0 | 13.5 | 9.0 | 2.0 | 2 | 3 | 3 | 1 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 12.00 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 55 | 15 | 0 | 2 | 1 | 4.66 | .351 | 1.62 | 10.9 | 3.7 | 5.3 | 29.0 | 35 | 18 | 15 | 7 | 12 | 17 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 6.21 |