| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 19 | 19 | 8 | 5 | 3.10 | .250 | 0.99 | 7.0 | 1.9 | 4.8 | 145.0 | 113 | 52 | 50 | 13 | 30 | 78 | 5 | 0 | 0 | 1 | 15 | 2 | 0 | 3.75 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 18 | 18 | 6 | 7 | 4.25 | .328 | 1.45 | 9.8 | 3.2 | 5.3 | 106.0 | 116 | 58 | 50 | 11 | 38 | 63 | 2 | 0 | 0 | 0 | 11 | 1 | 3 | 4.26 |
| SP | Chesbro, J.Chesbro, Jack # >> | 30 | 1904 | R | 65 | 18 | 18 | 3 | 10 | 6.66 | .338 | 1.52 | 10.7 | 2.9 | 5.2 | 104.0 | 124 | 81 | 77 | 19 | 34 | 60 | 1 | 0 | 0 | 0 | 3 | 1 | 4 | 5.23 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 18 | 18 | 5 | 8 | 6.10 | .340 | 1.55 | 10.1 | 4.0 | 4.2 | 82.2 | 92 | 62 | 56 | 13 | 36 | 38 | 0 | 0 | 0 | 0 | 6 | 0 | 5 | 5.45 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 49 | 0 | 7 | 3 | 4.40 | .326 | 1.40 | 9.0 | 3.7 | 9.5 | 59.1 | 59 | 29 | 29 | 13 | 24 | 62 | 0 | 4 | 3 | 0 | 0 | 3 | 1 | 5.14 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 48 | 0 | 4 | 0 | 3.63 | .272 | 1.10 | 7.7 | 2.3 | 8.6 | 67.0 | 57 | 27 | 27 | 8 | 17 | 64 | 0 | 5 | 2 | 0 | 0 | 1 | 2 | 3.45 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 36 | 0 | 4 | 2 | 4.02 | .277 | 1.13 | 5.9 | 4.2 | 6.3 | 47.0 | 31 | 22 | 21 | 8 | 22 | 33 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 5.28 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 1 | 0 | 0 | 0 | 10.80 | .500 | 3.00 | 45.0 | 0.0 | 0.0 | 1.2 | 5 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 8 | 0 | 0 | 0 | 3.12 | .316 | 1.38 | 11.3 | 2.3 | 7.9 | 8.2 | 10 | 3 | 3 | 0 | 2 | 7 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 2.00 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 26 | 0 | 1 | 4 | 7.91 | .412 | 2.10 | 11.9 | 7.1 | 7.6 | 52.1 | 69 | 46 | 46 | 6 | 41 | 44 | 0 | 3 | 1 | 0 | 0 | 0 | 2 | 5.17 |