| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 30 | 30 | 8 | 11 | 4.36 | .302 | 1.28 | 9.1 | 2.4 | 7.3 | 208.2 | 211 | 113 | 101 | 29 | 56 | 169 | 2 | 0 | 0 | 0 | 16 | 4 | 3 | 4.05 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 30 | 30 | 10 | 10 | 4.63 | .313 | 1.33 | 8.7 | 3.3 | 7.0 | 202.1 | 195 | 110 | 104 | 24 | 75 | 156 | 4 | 0 | 0 | 0 | 16 | 6 | 4 | 4.20 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 29 | 29 | 5 | 17 | 7.16 | .372 | 1.76 | 11.8 | 4.0 | 7.2 | 161.0 | 211 | 137 | 128 | 30 | 72 | 128 | 0 | 0 | 0 | 0 | 9 | 3 | 3 | 5.23 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 31 | 29 | 12 | 10 | 4.20 | .309 | 1.33 | 8.6 | 3.4 | 5.8 | 207.2 | 198 | 99 | 97 | 32 | 79 | 134 | 8 | 1 | 0 | 1 | 15 | 2 | 6 | 4.89 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 74 | 0 | 5 | 13 | 2.42 | .253 | 1.00 | 6.2 | 2.9 | 8.0 | 85.2 | 59 | 28 | 23 | 9 | 27 | 76 | 0 | 30 | 5 | 0 | 0 | 1 | 1 | 3.58 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 83 | 0 | 3 | 2 | 2.37 | .265 | 1.07 | 6.4 | 3.3 | 9.4 | 102.2 | 73 | 30 | 27 | 14 | 37 | 107 | 0 | 2 | 4 | 0 | 0 | 1 | 0 | 3.80 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 83 | 60 | 0 | 2 | 5 | 5.43 | .349 | 1.59 | 10.4 | 4.1 | 8.7 | 64.2 | 74 | 43 | 39 | 16 | 29 | 62 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 5.72 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 52 | 0 | 2 | 2 | 5.34 | .342 | 1.56 | 9.6 | 4.4 | 10.2 | 59.0 | 63 | 36 | 35 | 10 | 29 | 67 | 0 | 3 | 1 | 0 | 0 | 0 | 4 | 4.41 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 47 | 0 | 3 | 5 | 5.34 | .346 | 1.57 | 10.6 | 3.6 | 10.3 | 57.1 | 67 | 36 | 34 | 6 | 23 | 65 | 0 | 1 | 2 | 0 | 0 | 1 | 1 | 3.35 |