| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 27 | 27 | 15 | 5 | 2.49 | .242 | 0.94 | 6.2 | 2.3 | 9.6 | 184.2 | 126 | 51 | 51 | 20 | 47 | 197 | 2 | 0 | 0 | 0 | 19 | 4 | 0 | 3.10 |
| SP | Gibson, B.Gibson, Bob # >> | 33 | 1968 | R | 92 | 26 | 26 | 13 | 6 | 2.88 | .251 | 0.99 | 6.8 | 2.1 | 5.4 | 184.2 | 140 | 63 | 59 | 14 | 42 | 111 | 10 | 0 | 0 | 2 | 17 | 4 | 1 | 3.53 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 26 | 26 | 12 | 8 | 3.47 | .286 | 1.15 | 8.1 | 2.3 | 7.1 | 171.0 | 153 | 70 | 66 | 12 | 44 | 135 | 3 | 0 | 0 | 0 | 17 | 8 | 1 | 3.25 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 26 | 26 | 10 | 8 | 3.90 | .309 | 1.29 | 7.5 | 4.2 | 4.5 | 157.0 | 130 | 69 | 68 | 11 | 73 | 79 | 2 | 0 | 0 | 0 | 13 | 8 | 2 | 4.45 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 71 | 0 | 1 | 3 | 4.08 | .294 | 1.22 | 9.2 | 1.9 | 8.6 | 81.2 | 83 | 40 | 37 | 12 | 17 | 77 | 0 | 1 | 4 | 0 | 0 | 2 | 0 | 3.73 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 52 | 0 | 7 | 1 | 2.50 | .276 | 1.13 | 6.9 | 3.3 | 6.2 | 68.1 | 52 | 19 | 19 | 7 | 25 | 47 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 4.10 |
| RP | Davis, W.Davis, Wade † >> | 29 | 2015 | R | 88 | 42 | 0 | 8 | 0 | 1.79 | .234 | 0.91 | 5.2 | 3.1 | 9.2 | 50.1 | 29 | 10 | 10 | 3 | 17 | 51 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2.76 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 25 | 0 | 1 | 1 | 2.29 | .284 | 1.19 | 5.7 | 5.1 | 9.3 | 35.1 | 22 | 9 | 9 | 2 | 20 | 36 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 3.40 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 26 | 0 | 2 | 2 | 2.86 | .331 | 1.48 | 7.7 | 5.8 | 8.4 | 28.1 | 24 | 9 | 9 | 1 | 18 | 26 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.54 |
| CL | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 95 | 63 | 0 | 2 | 3 | 2.33 | .242 | 0.93 | 5.1 | 3.3 | 8.6 | 65.2 | 37 | 17 | 17 | 5 | 24 | 62 | 0 | 38 | 3 | 0 | 0 | 2 | 0 | 3.29 |