| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 26 | 26 | 14 | 5 | 2.55 | .242 | 0.93 | 6.1 | 2.3 | 9.8 | 176.2 | 120 | 50 | 50 | 20 | 45 | 192 | 2 | 0 | 0 | 0 | 18 | 4 | 0 | 3.13 |
| SP | Gibson, B.Gibson, Bob # >> | 33 | 1968 | R | 92 | 25 | 25 | 13 | 5 | 2.70 | .248 | 0.96 | 6.7 | 2.1 | 5.4 | 180.1 | 133 | 58 | 54 | 14 | 41 | 108 | 10 | 0 | 0 | 2 | 17 | 4 | 1 | 3.56 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 24 | 24 | 12 | 7 | 3.36 | .281 | 1.12 | 7.7 | 2.4 | 7.1 | 158.0 | 135 | 63 | 59 | 11 | 42 | 125 | 3 | 0 | 0 | 0 | 16 | 8 | 1 | 3.27 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 24 | 24 | 9 | 8 | 4.00 | .314 | 1.32 | 7.7 | 4.2 | 4.6 | 144.0 | 123 | 65 | 64 | 10 | 67 | 73 | 2 | 0 | 0 | 0 | 12 | 8 | 2 | 4.45 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 67 | 0 | 1 | 3 | 4.24 | .295 | 1.23 | 9.4 | 1.8 | 8.8 | 76.1 | 79 | 39 | 36 | 12 | 15 | 74 | 0 | 1 | 4 | 0 | 0 | 2 | 0 | 3.78 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 49 | 0 | 5 | 1 | 2.69 | .277 | 1.13 | 7.0 | 3.3 | 6.1 | 63.2 | 49 | 19 | 19 | 7 | 23 | 43 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 4.22 |
| RP | Davis, W.Davis, Wade † >> | 29 | 2015 | R | 88 | 39 | 0 | 7 | 0 | 1.97 | .239 | 0.94 | 5.4 | 3.2 | 9.4 | 45.2 | 27 | 10 | 10 | 3 | 16 | 47 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.84 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 24 | 0 | 1 | 1 | 2.41 | .289 | 1.22 | 5.7 | 5.5 | 9.3 | 33.2 | 21 | 9 | 9 | 2 | 20 | 34 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 3.55 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 25 | 0 | 2 | 2 | 3.12 | .345 | 1.58 | 8.0 | 6.2 | 8.3 | 26.0 | 23 | 9 | 9 | 1 | 18 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.73 |
| CL | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 95 | 59 | 0 | 2 | 3 | 2.51 | .247 | 0.95 | 5.0 | 3.5 | 8.4 | 61.0 | 34 | 17 | 17 | 5 | 24 | 57 | 0 | 35 | 3 | 0 | 0 | 2 | 0 | 3.48 |