| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 25 | 25 | 11 | 10 | 3.91 | .303 | 1.29 | 9.1 | 2.6 | 6.2 | 186.2 | 188 | 88 | 81 | 19 | 53 | 128 | 6 | 0 | 0 | 2 | 13 | 2 | 1 | 3.84 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 24 | 24 | 9 | 12 | 5.97 | .338 | 1.50 | 11.2 | 2.4 | 5.5 | 159.2 | 197 | 111 | 106 | 25 | 42 | 97 | 4 | 0 | 0 | 1 | 8 | 6 | 4 | 4.73 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 24 | 24 | 7 | 14 | 6.36 | .357 | 1.65 | 10.9 | 4.0 | 5.2 | 157.0 | 190 | 119 | 111 | 30 | 69 | 90 | 2 | 0 | 0 | 1 | 6 | 2 | 11 | 5.69 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 57 | 0 | 2 | 1 | 4.55 | .287 | 1.21 | 7.3 | 3.6 | 9.7 | 65.1 | 53 | 34 | 33 | 4 | 26 | 70 | 0 | 2 | 2 | 0 | 0 | 0 | 3 | 2.85 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 41 | 0 | 1 | 1 | 4.29 | .315 | 1.38 | 9.6 | 2.8 | 7.9 | 42.0 | 45 | 21 | 20 | 5 | 13 | 37 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.71 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 24 | 0 | 3 | 1 | 2.57 | .232 | 0.90 | 4.7 | 3.4 | 7.3 | 21.0 | 11 | 6 | 6 | 1 | 8 | 17 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 3.14 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 39 | 0 | 2 | 8 | 4.62 | .278 | 1.15 | 7.8 | 2.5 | 8.5 | 39.0 | 34 | 21 | 20 | 5 | 11 | 37 | 0 | 25 | 2 | 0 | 0 | 0 | 1 | 3.62 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 11 | 0 | 0 | 0 | 4.56 | .336 | 1.46 | 9.9 | 3.4 | 5.1 | 51.1 | 56 | 27 | 26 | 4 | 19 | 29 | 0 | 0 | 0 | 0 | 0 | 3 | 2 | 4.18 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 35 | 0 | 1 | 0 | 2.63 | .327 | 1.41 | 7.8 | 5.1 | 8.3 | 37.2 | 32 | 11 | 11 | 0 | 21 | 34 | 0 | 2 | 3 | 0 | 0 | 2 | 0 | 3.03 |