| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 16 | 16 | 7 | 5 | 3.50 | .274 | 1.07 | 7.6 | 2.1 | 8.7 | 105.1 | 89 | 43 | 41 | 10 | 24 | 102 | 0 | 0 | 0 | 0 | 9 | 6 | 0 | 3.15 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 76 | 15 | 15 | 8 | 5 | 4.21 | .335 | 1.48 | 9.8 | 3.6 | 4.4 | 113.1 | 123 | 64 | 53 | 11 | 45 | 55 | 4 | 0 | 0 | 0 | 8 | 3 | 2 | 4.57 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 15 | 15 | 6 | 6 | 4.82 | .345 | 1.57 | 10.4 | 3.7 | 5.0 | 106.1 | 123 | 59 | 57 | 6 | 44 | 59 | 4 | 0 | 0 | 0 | 8 | 1 | 2 | 3.90 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 34 | 0 | 2 | 2 | 4.21 | .283 | 1.10 | 7.3 | 2.8 | 8.0 | 36.1 | 29 | 18 | 17 | 5 | 11 | 32 | 0 | 1 | 1 | 0 | 0 | 3 | 2 | 4.19 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 24 | 0 | 4 | 1 | 6.04 | .296 | 1.26 | 9.0 | 2.5 | 7.2 | 25.1 | 25 | 17 | 17 | 1 | 7 | 20 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 2.76 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 11 | 0 | 0 | 1 | 13.50 | .429 | 2.25 | 13.5 | 9.0 | 6.0 | 6.2 | 9 | 11 | 10 | 3 | 6 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 11.17 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 25 | 0 | 1 | 6 | 4.73 | .259 | 1.01 | 6.9 | 2.4 | 10.4 | 26.2 | 20 | 14 | 14 | 4 | 7 | 30 | 0 | 13 | 3 | 0 | 0 | 1 | 1 | 3.62 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 5 | 0 | 0 | 0 | 1.35 | .231 | 0.90 | 6.0 | 3.0 | 6.0 | 6.2 | 4 | 1 | 1 | 1 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.83 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 84 | 4 | 0 | 1 | 0 | 2.08 | .288 | 1.21 | 9.0 | 2.1 | 3.7 | 17.1 | 17 | 5 | 4 | 2 | 4 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.41 |