| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 13 | 13 | 6 | 4 | 3.91 | .313 | 1.34 | 9.7 | 2.4 | 4.8 | 94.1 | 101 | 47 | 41 | 6 | 25 | 50 | 1 | 0 | 0 | 1 | 7 | 3 | 1 | 3.66 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 13 | 13 | 5 | 3 | 3.03 | .313 | 1.36 | 8.5 | 3.7 | 7.5 | 92.0 | 87 | 37 | 31 | 9 | 38 | 77 | 0 | 0 | 0 | 0 | 9 | 1 | 1 | 3.87 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 13 | 13 | 6 | 6 | 4.58 | .318 | 1.39 | 9.5 | 3.1 | 5.4 | 94.1 | 99 | 53 | 48 | 12 | 32 | 56 | 2 | 0 | 0 | 1 | 5 | 1 | 4 | 4.52 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 13 | 13 | 5 | 6 | 7.48 | .370 | 1.75 | 12.0 | 3.8 | 6.0 | 80.2 | 107 | 73 | 67 | 21 | 34 | 53 | 1 | 0 | 0 | 0 | 3 | 1 | 2 | 6.40 |
| CL | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 27 | 0 | 4 | 5 | 4.67 | .325 | 1.44 | 9.7 | 3.3 | 11.0 | 27.0 | 29 | 15 | 14 | 4 | 10 | 33 | 0 | 14 | 3 | 0 | 0 | 0 | 1 | 3.59 |
| SU | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 28 | 0 | 0 | 0 | 3.18 | .303 | 1.27 | 6.1 | 5.5 | 9.6 | 28.1 | 19 | 11 | 10 | 1 | 17 | 30 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 3.25 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 33 | 0 | 0 | 1 | 3.24 | .333 | 1.50 | 9.3 | 4.4 | 8.5 | 33.1 | 34 | 14 | 12 | 5 | 16 | 31 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 4.55 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 25 | 0 | 2 | 2 | 2.08 | .316 | 1.38 | 6.2 | 6.2 | 8.3 | 26.0 | 18 | 6 | 6 | 1 | 18 | 24 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.73 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 13 | 0 | 0 | 0 | 1.50 | .379 | 1.83 | 9.0 | 7.5 | 9.0 | 12.0 | 12 | 3 | 2 | 1 | 10 | 12 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 4.58 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 2 | 0 | 1 | 0 | 9.00 | .333 | 1.50 | 13.5 | 0.0 | 4.5 | 2.0 | 3 | 2 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 8.50 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 10 | 0 | 1 | 0 | 5.40 | .405 | 2.04 | 11.3 | 7.9 | 6.8 | 8.1 | 10 | 7 | 5 | 1 | 7 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.75 |