| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 13 | 13 | 3 | 5 | 3.43 | .281 | 1.18 | 8.2 | 2.4 | 8.4 | 97.0 | 88 | 42 | 37 | 14 | 26 | 90 | 1 | 0 | 0 | 0 | 8 | 0 | 4 | 3.82 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 13 | 13 | 8 | 3 | 3.66 | .314 | 1.36 | 7.7 | 4.5 | 7.1 | 86.0 | 74 | 37 | 35 | 6 | 43 | 68 | 1 | 0 | 0 | 0 | 8 | 1 | 0 | 3.86 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 13 | 13 | 5 | 6 | 5.13 | .348 | 1.56 | 11.0 | 3.0 | 7.7 | 86.0 | 105 | 50 | 49 | 13 | 29 | 74 | 1 | 0 | 0 | 0 | 5 | 4 | 2 | 4.40 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 13 | 13 | 6 | 6 | 4.78 | .330 | 1.46 | 9.6 | 3.6 | 5.1 | 84.2 | 90 | 49 | 45 | 14 | 34 | 48 | 1 | 0 | 0 | 0 | 5 | 1 | 2 | 5.27 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 13 | 13 | 7 | 5 | 4.68 | .318 | 1.36 | 8.3 | 4.0 | 6.6 | 92.1 | 85 | 48 | 48 | 13 | 41 | 67 | 1 | 0 | 0 | 1 | 6 | 3 | 5 | 4.82 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 24 | 0 | 0 | 2 | 3.33 | .277 | 1.11 | 7.5 | 2.6 | 11.3 | 24.1 | 20 | 9 | 9 | 1 | 7 | 30 | 0 | 18 | 3 | 0 | 0 | 1 | 1 | 2.04 |
| SU | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 22 | 0 | 1 | 0 | 3.68 | .275 | 1.14 | 9.4 | 0.8 | 8.6 | 22.0 | 23 | 13 | 9 | 3 | 2 | 21 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.14 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 24 | 0 | 2 | 3 | 2.35 | .303 | 1.30 | 6.3 | 5.5 | 7.8 | 23.0 | 16 | 6 | 6 | 1 | 14 | 20 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.65 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 9 | 0 | 1 | 1 | 2.35 | .343 | 1.57 | 10.3 | 5.1 | 7.7 | 7.2 | 8 | 2 | 2 | 1 | 4 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.86 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 8 | 0 | 0 | 0 | 2.70 | .375 | 1.80 | 16.5 | 1.5 | 15.0 | 6.2 | 11 | 2 | 2 | 0 | 1 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.17 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 6 | 0 | 0 | 0 | 0.00 | .182 | 0.67 | 3.0 | 3.0 | 11.0 | 9.0 | 3 | 0 | 0 | 0 | 3 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.56 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |