| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 28 | 28 | 14 | 8 | 3.02 | .259 | 1.02 | 7.4 | 1.8 | 8.5 | 208.1 | 172 | 80 | 70 | 21 | 41 | 197 | 5 | 0 | 0 | 4 | 20 | 6 | 3 | 3.10 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 27 | 27 | 8 | 12 | 4.14 | .285 | 1.16 | 7.8 | 2.7 | 6.8 | 189.1 | 163 | 91 | 87 | 18 | 56 | 143 | 4 | 0 | 0 | 1 | 16 | 7 | 3 | 3.72 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 26 | 26 | 10 | 10 | 3.75 | .292 | 1.23 | 7.3 | 3.9 | 5.1 | 165.2 | 133 | 70 | 69 | 15 | 71 | 94 | 0 | 0 | 0 | 0 | 14 | 1 | 3 | 4.35 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 51 | 23 | 23 | 10 | 7 | 3.99 | .269 | 1.09 | 7.1 | 2.7 | 5.0 | 155.2 | 122 | 70 | 69 | 13 | 47 | 86 | 6 | 0 | 0 | 1 | 13 | 3 | 4 | 3.95 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 56 | 0 | 7 | 6 | 1.85 | .226 | 0.84 | 5.6 | 2.0 | 8.8 | 58.1 | 36 | 15 | 12 | 4 | 13 | 57 | 0 | 34 | 3 | 0 | 0 | 2 | 2 | 2.71 |
| SU | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 48 | 0 | 1 | 1 | 4.15 | .313 | 1.37 | 7.8 | 4.5 | 11.3 | 52.0 | 45 | 25 | 24 | 9 | 26 | 65 | 0 | 4 | 7 | 0 | 0 | 0 | 2 | 4.25 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 32 | 0 | 3 | 2 | 1.17 | .233 | 0.85 | 5.1 | 2.7 | 12.3 | 30.2 | 17 | 4 | 4 | 1 | 9 | 41 | 0 | 2 | 0 | 0 | 0 | 2 | 1 | 1.80 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 17 | 0 | 2 | 1 | 3.78 | .286 | 1.20 | 7.3 | 3.9 | 8.4 | 16.2 | 13 | 7 | 7 | 1 | 7 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.25 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 14 | 2 | 2 | 2 | 3.09 | .285 | 1.16 | 8.1 | 2.4 | 5.9 | 67.0 | 60 | 26 | 23 | 7 | 18 | 44 | 1 | 0 | 0 | 0 | 0 | 2 | 1 | 3.94 |