| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 97 | 29 | 29 | 11 | 10 | 5.10 | .326 | 1.42 | 9.4 | 3.4 | 9.4 | 187.0 | 195 | 106 | 106 | 26 | 71 | 195 | 1 | 0 | 0 | 0 | 15 | 5 | 6 | 3.94 |
| SP | Harden, R.Harden, Rich # >> | 27 | 2008 | R | 68 | 28 | 28 | 10 | 9 | 4.70 | .316 | 1.35 | 8.0 | 4.2 | 8.8 | 168.2 | 149 | 88 | 88 | 18 | 79 | 165 | 0 | 0 | 0 | 0 | 17 | 6 | 2 | 3.95 |
| SP | Hamels, C.Hamels, Cole >> | 28 | 2011 | L | 63 | 27 | 27 | 6 | 15 | 4.84 | .326 | 1.43 | 9.8 | 3.1 | 6.4 | 182.1 | 198 | 101 | 98 | 28 | 63 | 129 | 1 | 0 | 0 | 0 | 12 | 3 | 6 | 4.67 |
| SP | Lincecum, T.Lincecum, Tim >> | 25 | 2009 | R | 59 | 27 | 27 | 9 | 12 | 3.84 | .317 | 1.36 | 8.7 | 3.6 | 10.0 | 192.0 | 185 | 86 | 82 | 25 | 76 | 213 | 2 | 0 | 0 | 0 | 17 | 6 | 10 | 3.76 |
| SP | Beckett, J.Beckett, Josh # >> | 31 | 2011 | R | 58 | 26 | 26 | 9 | 10 | 5.51 | .306 | 1.30 | 8.5 | 3.3 | 6.7 | 156.2 | 147 | 96 | 96 | 27 | 57 | 116 | 1 | 0 | 0 | 0 | 11 | 3 | 5 | 4.92 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 77 | 0 | 3 | 4 | 3.57 | .279 | 1.12 | 6.5 | 3.6 | 8.7 | 106.0 | 77 | 42 | 42 | 8 | 42 | 103 | 0 | 4 | 3 | 0 | 0 | 4 | 0 | 3.34 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 74 | 73 | 0 | 5 | 1 | 2.60 | .258 | 1.04 | 7.0 | 2.4 | 10.9 | 97.0 | 75 | 28 | 28 | 12 | 26 | 117 | 0 | 10 | 6 | 0 | 0 | 0 | 2 | 3.00 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 62 | 52 | 0 | 4 | 6 | 5.40 | .330 | 1.44 | 10.2 | 3.0 | 8.1 | 61.2 | 69 | 37 | 37 | 16 | 20 | 55 | 0 | 3 | 5 | 0 | 0 | 2 | 1 | 5.69 |
| RP | Pressly, R.Pressly, Ryan >> | 30 | 2019 | R | 54 | 44 | 0 | 3 | 4 | 5.37 | .306 | 1.32 | 8.8 | 3.2 | 8.2 | 53.2 | 52 | 32 | 32 | 10 | 19 | 48 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 4.72 |
| SP | Weaver, J.Weaver, Jered >> | 29 | 2011 | R | 54 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Garrelts, S.Garrelts, Scott >> | 28 | 1989 | R | 51 | 1 | 0 | 0 | 0 | 0.00 | .167 | 0.60 | 9.0 | 0.0 | 9.0 | 1.2 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1.00 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 57 | 24 | 0 | 4 | 2 | 4.57 | .326 | 1.40 | 8.3 | 4.4 | 7.0 | 41.1 | 38 | 21 | 21 | 8 | 20 | 32 | 0 | 5 | 1 | 0 | 0 | 2 | 0 | 5.59 |