| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 29 | 29 | 15 | 7 | 2.85 | .265 | 1.06 | 7.0 | 2.5 | 11.1 | 195.2 | 152 | 62 | 62 | 19 | 55 | 240 | 1 | 0 | 0 | 1 | 21 | 5 | 0 | 2.73 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 76 | 28 | 28 | 12 | 10 | 4.48 | .309 | 1.31 | 8.0 | 3.9 | 6.7 | 191.0 | 169 | 96 | 95 | 27 | 82 | 143 | 5 | 0 | 0 | 1 | 13 | 5 | 5 | 4.71 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 72 | 28 | 28 | 10 | 7 | 4.63 | .307 | 1.31 | 9.1 | 2.8 | 7.4 | 161.1 | 162 | 83 | 83 | 23 | 50 | 133 | 0 | 0 | 0 | 0 | 13 | 2 | 1 | 4.17 |
| SP | Clemens, R.Clemens, Roger # >> | 24 | 1986 | R | 79 | 27 | 27 | 14 | 8 | 5.00 | .320 | 1.39 | 8.6 | 3.9 | 6.8 | 185.1 | 177 | 104 | 103 | 30 | 80 | 139 | 3 | 0 | 0 | 1 | 8 | 5 | 10 | 4.98 |
| RP | Kimbrel, C.Kimbrel, Craig # >> | 24 | 2012 | R | 100 | 73 | 0 | 3 | 3 | 4.26 | .290 | 1.21 | 6.9 | 4.0 | 10.3 | 99.1 | 76 | 47 | 47 | 15 | 44 | 113 | 0 | 4 | 4 | 0 | 0 | 2 | 5 | 4.08 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 87 | 66 | 0 | 4 | 2 | 2.82 | .281 | 1.16 | 6.5 | 3.9 | 10.1 | 73.1 | 53 | 27 | 23 | 10 | 32 | 82 | 0 | 2 | 3 | 0 | 0 | 1 | 1 | 3.89 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 28 | 0 | 3 | 3 | 8.06 | .446 | 2.34 | 10.4 | 11.2 | 9.0 | 25.2 | 29 | 23 | 23 | 7 | 31 | 25 | 0 | 2 | 2 | 0 | 0 | 2 | 1 | 8.60 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 69 | 30 | 0 | 1 | 2 | 3.38 | .296 | 1.23 | 7.3 | 3.9 | 10.5 | 37.1 | 30 | 14 | 14 | 2 | 16 | 43 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 2.76 |
| CL | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 84 | 64 | 0 | 2 | 6 | 2.55 | .264 | 1.07 | 7.5 | 2.1 | 8.6 | 67.0 | 56 | 19 | 19 | 7 | 16 | 64 | 0 | 41 | 2 | 0 | 0 | 0 | 1 | 3.16 |