| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 87 | 18 | 18 | 7 | 7 | 5.15 | .322 | 1.40 | 8.8 | 3.8 | 8.2 | 117.0 | 114 | 67 | 67 | 19 | 50 | 106 | 1 | 0 | 0 | 0 | 8 | 3 | 8 | 4.66 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 77 | 18 | 18 | 10 | 3 | 3.31 | .304 | 1.29 | 7.8 | 3.8 | 5.3 | 117.0 | 102 | 44 | 43 | 15 | 49 | 69 | 1 | 0 | 0 | 0 | 11 | 2 | 0 | 4.79 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 73 | 18 | 18 | 8 | 4 | 4.43 | .319 | 1.38 | 9.6 | 2.9 | 6.9 | 113.2 | 121 | 58 | 56 | 15 | 36 | 87 | 0 | 0 | 0 | 0 | 9 | 3 | 2 | 4.22 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 64 | 17 | 17 | 9 | 2 | 4.19 | .302 | 1.28 | 8.8 | 2.7 | 6.1 | 118.0 | 115 | 55 | 55 | 24 | 36 | 80 | 4 | 0 | 0 | 1 | 9 | 2 | 4 | 5.25 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 49 | 0 | 3 | 0 | 2.63 | .232 | 0.88 | 6.5 | 1.5 | 9.8 | 68.1 | 49 | 21 | 20 | 10 | 11 | 74 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 3.31 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 42 | 0 | 4 | 1 | 2.26 | .255 | 1.01 | 6.7 | 2.5 | 10.1 | 51.2 | 38 | 13 | 13 | 3 | 14 | 57 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 2.41 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 78 | 30 | 0 | 4 | 2 | 3.64 | .336 | 1.48 | 6.5 | 7.1 | 8.4 | 29.2 | 21 | 12 | 12 | 4 | 23 | 27 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 5.41 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 72 | 22 | 0 | 2 | 2 | 3.04 | .245 | 0.89 | 5.5 | 2.7 | 10.6 | 23.2 | 14 | 10 | 8 | 2 | 7 | 27 | 0 | 1 | 0 | 0 | 0 | 2 | 2 | 2.96 |
| CL | Eckersley, D.Eckersley, Dennis † >> | 36 | 1990 | R | 86 | 43 | 0 | 6 | 2 | 2.51 | .227 | 0.86 | 6.3 | 1.6 | 8.0 | 46.2 | 32 | 13 | 13 | 4 | 8 | 41 | 0 | 26 | 3 | 0 | 0 | 1 | 0 | 2.93 |