| SP | Skubal, T.Skubal, Tarik # $ >> | 28 | 2025 | L | 100 | 34 | 34 | 8 | 13 | 3.35 | .281 | 1.12 | 8.0 | 2.1 | 10.7 | 217.2 | 194 | 81 | 81 | 20 | 50 | 258 | 0 | 0 | 0 | 0 | 22 | 11 | 2 | 2.66 |
| SP | Glasnow, T.Glasnow, Tyler >> | 31 | 2025 | R | 88 | 31 | 31 | 13 | 6 | 3.86 | .311 | 1.31 | 8.0 | 3.8 | 10.2 | 156.1 | 139 | 67 | 67 | 23 | 66 | 176 | 0 | 0 | 0 | 0 | 9 | 7 | 4 | 4.06 |
| SP | Imanaga, S.Imanaga, Shota # $ >> | 31 | 2025 | L | 83 | 32 | 32 | 11 | 11 | 4.53 | .315 | 1.32 | 8.6 | 3.2 | 8.1 | 175.0 | 168 | 89 | 88 | 20 | 63 | 157 | 0 | 0 | 0 | 0 | 16 | 10 | 3 | 3.94 |
| SP | Abbott, A.Abbott, Andrew >> | 26 | 2025 | L | 71 | 33 | 32 | 9 | 7 | 4.08 | .310 | 1.32 | 9.0 | 2.9 | 7.9 | 154.1 | 154 | 73 | 70 | 21 | 50 | 136 | 0 | 1 | 0 | 0 | 4 | 4 | 4 | 4.06 |
| SP | Woods Richardson, S.Woods Richardson, Simeon >> | 24 | 2025 | R | 60 | 33 | 30 | 2 | 6 | 3.69 | .323 | 1.41 | 8.7 | 4.1 | 7.5 | 119.2 | 115 | 50 | 49 | 21 | 54 | 99 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 5.04 |
| RP | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 100 | 100 | 0 | 10 | 2 | 2.54 | .266 | 1.09 | 5.0 | 4.8 | 11.3 | 120.1 | 67 | 35 | 34 | 7 | 64 | 151 | 0 | 0 | 3 | 0 | 0 | 0 | 5 | 2.84 |
| RP | Jansen, K.Jansen, Kenley † $ >> | 37 | 2025 | R | 89 | 98 | 0 | 11 | 3 | 2.92 | .270 | 1.07 | 6.5 | 3.2 | 8.0 | 117.0 | 84 | 43 | 38 | 8 | 41 | 104 | 0 | 4 | 1 | 0 | 0 | 5 | 0 | 3.29 |
| RP | Miller, S.Miller, Shelby >> | 34 | 2025 | R | 82 | 95 | 0 | 6 | 6 | 3.19 | .278 | 1.14 | 6.8 | 3.4 | 10.6 | 110.0 | 83 | 39 | 39 | 14 | 42 | 130 | 0 | 16 | 6 | 0 | 0 | 2 | 1 | 3.49 |
| RP | Bender, A.Bender, Anthony >> | 30 | 2025 | R | 77 | 68 | 0 | 5 | 4 | 3.51 | .329 | 1.46 | 7.6 | 5.6 | 8.2 | 66.2 | 56 | 27 | 26 | 7 | 41 | 60 | 0 | 11 | 7 | 0 | 0 | 1 | 3 | 4.47 |
| RP | Sterner, J.Sterner, Justin >> | 28 | 2025 | R | 77 | 49 | 0 | 5 | 2 | 2.60 | .314 | 1.36 | 7.4 | 4.9 | 9.2 | 55.1 | 45 | 17 | 16 | 5 | 30 | 56 | 0 | 6 | 0 | 0 | 0 | 1 | 0 | 3.84 |
| SP | Giolito, L.Giolito, Lucas >> | 30 | 2025 | R | 47 | 21 | 3 | 4 | 2 | 3.40 | .328 | 1.47 | 8.8 | 4.4 | 6.2 | 45.0 | 44 | 21 | 17 | 3 | 22 | 31 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 3.96 |