| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 21 | 21 | 7 | 6 | 3.62 | .291 | 1.21 | 8.5 | 2.4 | 9.0 | 131.2 | 124 | 56 | 53 | 14 | 35 | 131 | 0 | 0 | 0 | 0 | 15 | 3 | 0 | 3.26 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 20 | 20 | 5 | 8 | 6.00 | .345 | 1.56 | 9.2 | 4.9 | 10.1 | 102.0 | 104 | 71 | 68 | 20 | 55 | 114 | 0 | 0 | 0 | 0 | 8 | 2 | 1 | 4.99 |
| SP | Sutton, D.Sutton, Don # >> | 27 | 1972 | R | 82 | 19 | 19 | 8 | 9 | 5.89 | .330 | 1.45 | 9.1 | 4.0 | 4.0 | 107.0 | 108 | 72 | 70 | 16 | 47 | 47 | 3 | 0 | 0 | 0 | 6 | 3 | 5 | 5.47 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 22 | 19 | 3 | 11 | 7.46 | .360 | 1.68 | 10.0 | 5.2 | 8.1 | 89.1 | 99 | 74 | 74 | 18 | 51 | 80 | 1 | 1 | 0 | 0 | 6 | 1 | 1 | 5.58 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 22 | 19 | 6 | 8 | 6.22 | .332 | 1.47 | 10.0 | 3.3 | 5.2 | 110.0 | 122 | 86 | 76 | 22 | 40 | 63 | 0 | 0 | 0 | 0 | 8 | 2 | 2 | 5.60 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 54 | 0 | 3 | 3 | 6.41 | .383 | 1.85 | 9.2 | 7.5 | 10.2 | 59.0 | 60 | 47 | 42 | 11 | 49 | 67 | 0 | 0 | 2 | 0 | 0 | 1 | 6 | 5.69 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 56 | 0 | 6 | 2 | 4.83 | .344 | 1.54 | 9.8 | 4.3 | 8.7 | 59.2 | 64 | 34 | 32 | 11 | 28 | 57 | 0 | 1 | 2 | 0 | 0 | 2 | 0 | 5.02 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 51 | 0 | 3 | 2 | 3.31 | .301 | 1.28 | 8.3 | 3.2 | 10.7 | 68.0 | 63 | 34 | 25 | 10 | 24 | 81 | 0 | 0 | 3 | 0 | 0 | 1 | 3 | 3.63 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 94 | 62 | 0 | 0 | 2 | 3.38 | .310 | 1.33 | 7.1 | 4.9 | 8.0 | 72.0 | 57 | 31 | 27 | 8 | 39 | 64 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 4.33 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 58 | 0 | 4 | 2 | 3.21 | .257 | 1.01 | 6.6 | 2.6 | 7.1 | 67.1 | 49 | 24 | 24 | 9 | 19 | 53 | 0 | 21 | 1 | 0 | 0 | 2 | 0 | 4.10 |