| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 35 | 35 | 17 | 9 | 3.91 | .276 | 1.13 | 7.6 | 2.6 | 9.0 | 223.0 | 188 | 101 | 97 | 21 | 64 | 223 | 1 | 0 | 0 | 1 | 20 | 3 | 0 | 3.13 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 34 | 34 | 9 | 14 | 5.22 | .322 | 1.42 | 9.3 | 3.5 | 9.0 | 189.2 | 195 | 119 | 110 | 29 | 74 | 190 | 1 | 0 | 0 | 0 | 16 | 1 | 3 | 4.17 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 83 | 0 | 4 | 3 | 2.63 | .273 | 1.09 | 6.0 | 3.8 | 6.9 | 96.0 | 64 | 32 | 28 | 8 | 41 | 74 | 0 | 2 | 0 | 0 | 0 | 3 | 0 | 3.92 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 61 | 0 | 3 | 3 | 4.63 | .311 | 1.35 | 10.5 | 1.7 | 7.5 | 68.0 | 79 | 37 | 35 | 11 | 13 | 57 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 4.00 |
| RP | Pagan, E.Pagan, Emilio # >> | 28 | 2019 | R | 77 | 47 | 0 | 5 | 4 | 6.40 | .304 | 1.31 | 8.0 | 3.8 | 8.2 | 45.0 | 40 | 35 | 32 | 8 | 19 | 41 | 0 | 1 | 2 | 0 | 0 | 0 | 2 | 4.76 |
| CL | Doolittle, S.Doolittle, Sean † $ >> | 31 | 2018 | L | 99 | 56 | 0 | 1 | 1 | 3.40 | .271 | 1.09 | 8.2 | 1.7 | 8.0 | 53.0 | 48 | 21 | 20 | 7 | 10 | 47 | 0 | 39 | 4 | 0 | 0 | 1 | 0 | 3.57 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 69 | 36 | 0 | 1 | 1 | 5.01 | .326 | 1.40 | 9.4 | 3.3 | 10.8 | 41.1 | 43 | 23 | 23 | 8 | 15 | 49 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.39 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 33 | 0 | 8 | 6 | 4.42 | .313 | 1.35 | 8.4 | 3.8 | 8.3 | 126.1 | 117 | 70 | 62 | 13 | 53 | 116 | 0 | 2 | 0 | 0 | 0 | 3 | 1 | 3.83 |