| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 13 | 13 | 8 | 3 | 3.96 | .315 | 1.36 | 9.1 | 3.1 | 7.7 | 86.1 | 87 | 42 | 38 | 10 | 30 | 74 | 3 | 0 | 0 | 0 | 7 | 2 | 0 | 3.91 |
| SP | Leonard, D.Leonard, Dutch $ >> | 22 | 1914 | L | 91 | 13 | 13 | 8 | 3 | 2.84 | .254 | 0.96 | 5.9 | 2.7 | 5.6 | 82.1 | 54 | 26 | 26 | 6 | 25 | 51 | 0 | 0 | 0 | 0 | 11 | 5 | 0 | 3.80 |
| SP | Mathewson, C.Mathewson, Christy # $ >> | 28 | 1908 | R | 82 | 12 | 12 | 3 | 6 | 4.46 | .281 | 1.16 | 9.4 | 1.2 | 5.0 | 76.2 | 79 | 39 | 38 | 10 | 10 | 42 | 3 | 0 | 0 | 1 | 6 | 1 | 1 | 4.04 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 76 | 12 | 12 | 6 | 5 | 5.51 | .316 | 1.36 | 9.4 | 2.9 | 6.1 | 81.2 | 85 | 52 | 50 | 17 | 26 | 55 | 3 | 0 | 0 | 1 | 5 | 2 | 2 | 5.41 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 36 | 0 | 1 | 1 | 4.30 | .298 | 1.20 | 7.6 | 3.3 | 10.2 | 44.0 | 37 | 21 | 21 | 6 | 16 | 50 | 0 | 5 | 1 | 0 | 0 | 3 | 3 | 3.80 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 22 | 0 | 1 | 0 | 1.35 | .248 | 0.96 | 7.4 | 1.4 | 7.6 | 33.1 | 27 | 5 | 5 | 1 | 5 | 28 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2.24 |
| RP | Miller, A.Miller, Andrew >> | 31 | 2016 | L | 91 | 18 | 0 | 0 | 1 | 2.86 | .275 | 1.14 | 7.0 | 3.3 | 6.5 | 22.0 | 17 | 7 | 7 | 3 | 8 | 16 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.41 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 12 | 0 | 2 | 1 | 3.07 | .302 | 1.30 | 7.7 | 4.5 | 7.7 | 14.2 | 12 | 5 | 5 | 2 | 7 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.64 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 12 | 0 | 0 | 1 | 6.39 | .377 | 1.82 | 10.5 | 6.8 | 11.3 | 12.2 | 14 | 9 | 9 | 1 | 9 | 15 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.83 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 10 | 0 | 0 | 2 | 4.91 | .313 | 1.36 | 9.8 | 2.5 | 4.9 | 11.0 | 12 | 6 | 6 | 2 | 3 | 6 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 5.09 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 12 | 0 | 0 | 0 | 4.38 | .327 | 1.46 | 9.0 | 4.5 | 4.5 | 12.1 | 12 | 9 | 6 | 1 | 6 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.58 |