| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 95 | 20 | 20 | 8 | 7 | 4.28 | .343 | 1.51 | 8.5 | 5.2 | 10.1 | 115.2 | 108 | 58 | 55 | 14 | 67 | 129 | 0 | 0 | 0 | 0 | 8 | 6 | 1 | 4.24 |
| SP | Duchscherer, J.Duchscherer, Justin >> | 31 | 2008 | R | 83 | 19 | 19 | 5 | 8 | 5.83 | .348 | 1.57 | 10.0 | 4.2 | 5.3 | 108.0 | 120 | 79 | 70 | 15 | 50 | 63 | 1 | 0 | 0 | 0 | 8 | 3 | 0 | 5.11 |
| SP | Loaiza, E.Loaiza, Esteban # >> | 32 | 2003 | R | 60 | 18 | 18 | 5 | 4 | 5.89 | .337 | 1.50 | 10.9 | 2.6 | 8.1 | 102.1 | 124 | 67 | 67 | 21 | 30 | 92 | 1 | 0 | 0 | 1 | 5 | 2 | 0 | 4.81 |
| CL | Valverde, J.Valverde, Jose † >> | 24 | 2003 | R | 79 | 33 | 0 | 1 | 2 | 2.76 | .279 | 1.16 | 5.3 | 5.3 | 11.5 | 29.1 | 17 | 9 | 9 | 1 | 17 | 37 | 0 | 23 | 3 | 0 | 0 | 0 | 2 | 2.66 |
| RP | Thornton, M.Thornton, Matt >> | 32 | 2008 | L | 52 | 51 | 0 | 1 | 2 | 3.35 | .268 | 1.10 | 7.3 | 2.6 | 8.3 | 48.1 | 39 | 18 | 18 | 6 | 14 | 44 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.67 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 84 | 48 | 0 | 3 | 4 | 4.61 | .291 | 1.20 | 8.0 | 2.9 | 10.0 | 52.2 | 46 | 28 | 27 | 11 | 17 | 58 | 0 | 0 | 3 | 0 | 0 | 2 | 2 | 4.62 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 44 | 0 | 3 | 2 | 4.31 | .299 | 1.28 | 8.4 | 3.2 | 9.8 | 56.1 | 52 | 28 | 27 | 8 | 20 | 61 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 3.75 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 29 | 2001 | R | 75 | 43 | 0 | 2 | 2 | 4.15 | .310 | 1.35 | 9.0 | 3.1 | 8.3 | 52.0 | 52 | 24 | 24 | 4 | 18 | 48 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.19 |
| RP | Isringhausen, J.Isringhausen, Jason >> | 32 | 2004 | R | 37 | 6 | 0 | 1 | 0 | 0.90 | .211 | 0.80 | 6.3 | 0.9 | 7.2 | 10.0 | 7 | 1 | 1 | 0 | 1 | 8 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1.70 |
| RP | Mota, G.Mota, Guillermo >> | 30 | 2003 | R | 48 | 24 | 0 | 3 | 1 | 6.23 | .400 | 1.96 | 14.9 | 2.8 | 7.6 | 26.0 | 43 | 21 | 18 | 5 | 8 | 22 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.85 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 73 | 18 | 18 | 2 | 6 | 5.50 | .350 | 1.55 | 10.0 | 4.1 | 6.3 | 73.2 | 81 | 50 | 45 | 14 | 33 | 51 | 0 | 0 | 0 | 0 | 0 | 5 | 2 | 5.66 |