| SP | Clemens, R.Clemens, Roger >> | 43 | 2005 | R | 94 | 32 | 32 | 5 | 17 | 4.99 | .334 | 1.49 | 9.8 | 3.6 | 8.6 | 202.0 | 219 | 114 | 112 | 32 | 81 | 192 | 1 | 0 | 0 | 0 | 17 | 4 | 2 | 4.42 |
| SP | Zambrano, C.Zambrano, Carlos # >> | 24 | 2005 | R | 70 | 32 | 32 | 13 | 11 | 4.74 | .330 | 1.44 | 8.8 | 4.2 | 7.3 | 207.0 | 203 | 109 | 109 | 29 | 96 | 168 | 0 | 0 | 0 | 0 | 13 | 7 | 4 | 4.69 |
| SP | Burkett, J.Burkett, John >> | 37 | 2001 | R | 50 | 31 | 31 | 7 | 11 | 5.99 | .350 | 1.59 | 10.2 | 4.2 | 7.6 | 156.1 | 176 | 122 | 104 | 33 | 73 | 132 | 0 | 0 | 0 | 0 | 10 | 3 | 5 | 5.52 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 34 | 31 | 31 | 5 | 13 | 5.02 | .344 | 1.55 | 8.7 | 5.4 | 6.5 | 157.2 | 151 | 98 | 88 | 25 | 94 | 114 | 0 | 0 | 0 | 0 | 10 | 3 | 1 | 5.47 |
| SP | Person, R.Person, Robert >> | 32 | 2001 | R | 23 | 34 | 31 | 12 | 13 | 5.55 | .343 | 1.56 | 9.9 | 4.2 | 7.1 | 180.0 | 197 | 121 | 111 | 36 | 83 | 142 | 0 | 0 | 0 | 0 | 15 | 2 | 12 | 5.44 |
| RP | Papelbon, J.Papelbon, Jonathan † >> | 26 | 2006 | R | 93 | 120 | 0 | 5 | 3 | 3.74 | .305 | 1.26 | 8.6 | 2.8 | 8.5 | 130.0 | 124 | 56 | 54 | 14 | 40 | 123 | 0 | 10 | 5 | 0 | 0 | 7 | 3 | 3.59 |
| RP | Jenks, B.Jenks, Bobby # >> | 26 | 2007 | R | 69 | 104 | 0 | 7 | 3 | 5.10 | .327 | 1.37 | 9.0 | 3.4 | 7.4 | 121.2 | 121 | 70 | 69 | 19 | 46 | 100 | 0 | 7 | 5 | 0 | 0 | 10 | 2 | 4.78 |
| RP | Vizcaino, L.Vizcaino, Luis >> | 28 | 2002 | R | 47 | 80 | 0 | 5 | 11 | 7.44 | .406 | 2.00 | 11.0 | 7.0 | 7.7 | 75.0 | 92 | 64 | 62 | 17 | 58 | 64 | 0 | 4 | 6 | 0 | 0 | 4 | 2 | 6.72 |
| RP | Howell, J.Howell, J.P. >> | 25 | 2008 | L | 32 | 116 | 0 | 2 | 7 | 4.59 | .323 | 1.38 | 8.5 | 4.0 | 8.6 | 100.0 | 94 | 65 | 51 | 22 | 44 | 96 | 0 | 6 | 5 | 0 | 0 | 5 | 4 | 5.41 |
| RP | Seanez, R.Seanez, Rudy >> | 37 | 2005 | R | 20 | 70 | 0 | 4 | 3 | 3.83 | .332 | 1.47 | 8.9 | 4.4 | 11.5 | 82.1 | 81 | 39 | 35 | 8 | 40 | 105 | 0 | 10 | 2 | 0 | 0 | 2 | 1 | 3.24 |