| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 93 | 32 | 32 | 13 | 14 | 3.99 | .295 | 1.21 | 9.0 | 1.9 | 8.7 | 212.0 | 212 | 99 | 94 | 28 | 45 | 206 | 3 | 0 | 0 | 1 | 19 | 9 | 3 | 3.54 |
| SP | Vazquez, J.Vazquez, Javier >> | 33 | 2009 | R | 88 | 31 | 31 | 12 | 8 | 5.42 | .319 | 1.38 | 9.7 | 2.7 | 8.7 | 201.0 | 217 | 122 | 121 | 43 | 60 | 195 | 2 | 0 | 0 | 1 | 12 | 5 | 3 | 4.81 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 67 | 31 | 31 | 7 | 18 | 5.50 | .329 | 1.42 | 10.7 | 2.1 | 7.3 | 186.2 | 221 | 117 | 114 | 37 | 44 | 151 | 3 | 0 | 0 | 0 | 14 | 9 | 3 | 4.82 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 57 | 32 | 30 | 7 | 18 | 6.36 | .344 | 1.51 | 10.7 | 2.9 | 6.3 | 178.1 | 212 | 138 | 126 | 41 | 57 | 124 | 5 | 1 | 0 | 1 | 8 | 12 | 3 | 5.76 |
| SU | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 60 | 0 | 1 | 1 | 5.37 | .304 | 1.26 | 7.9 | 3.6 | 9.0 | 58.2 | 51 | 35 | 35 | 9 | 23 | 58 | 0 | 8 | 5 | 0 | 0 | 3 | 5 | 4.36 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 76 | 83 | 0 | 4 | 1 | 4.13 | .308 | 1.27 | 9.1 | 2.4 | 9.5 | 104.2 | 105 | 49 | 48 | 18 | 28 | 110 | 0 | 2 | 2 | 0 | 0 | 7 | 0 | 4.14 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 67 | 72 | 0 | 4 | 3 | 5.60 | .323 | 1.42 | 9.9 | 2.9 | 9.6 | 80.1 | 88 | 51 | 50 | 17 | 26 | 85 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 4.65 |
| RP | Timlin, M.Timlin, Mike >> | 36 | 2002 | R | 50 | 56 | 0 | 2 | 3 | 4.95 | .313 | 1.29 | 9.3 | 2.4 | 5.0 | 67.1 | 69 | 42 | 37 | 13 | 18 | 37 | 0 | 1 | 1 | 0 | 0 | 5 | 2 | 5.45 |
| RP | Turnbow, D.Turnbow, Derrick >> | 27 | 2005 | R | 35 | 50 | 0 | 6 | 1 | 4.31 | .321 | 1.40 | 7.7 | 5.0 | 6.8 | 56.1 | 48 | 29 | 27 | 10 | 31 | 42 | 0 | 0 | 0 | 0 | 0 | 1 | 7 | 5.54 |