| SP | Hernandez, F.Hernandez, Felix >> | 19 | 2005 | R | 96 | 23 | 23 | 8 | 10 | 3.96 | .317 | 1.37 | 9.1 | 3.3 | 6.3 | 163.2 | 165 | 75 | 72 | 17 | 60 | 115 | 4 | 0 | 0 | 1 | 15 | 3 | 6 | 4.10 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 20 | 20 | 3 | 6 | 4.21 | .327 | 1.45 | 9.7 | 3.4 | 5.5 | 87.2 | 94 | 43 | 41 | 13 | 33 | 53 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 4.90 |
| SP | Buehrle, M.Buehrle, Mark † # >> | 22 | 2001 | L | 68 | 22 | 22 | 12 | 4 | 3.93 | .291 | 1.21 | 8.4 | 2.5 | 6.7 | 155.2 | 145 | 69 | 68 | 18 | 43 | 115 | 6 | 0 | 0 | 3 | 13 | 4 | 3 | 3.94 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 94 | 54 | 0 | 6 | 2 | 3.77 | .277 | 1.14 | 7.4 | 2.8 | 10.2 | 74.0 | 61 | 32 | 31 | 13 | 23 | 84 | 0 | 5 | 3 | 0 | 0 | 1 | 0 | 3.99 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 55 | 53 | 0 | 4 | 2 | 4.50 | .321 | 1.40 | 9.3 | 3.3 | 6.1 | 62.0 | 64 | 32 | 31 | 6 | 23 | 42 | 0 | 8 | 2 | 0 | 0 | 1 | 0 | 4.06 |
| RP | Donnelly, B.Donnelly, Brendan >> | 32 | 2003 | R | 37 | 41 | 0 | 4 | 0 | 2.68 | .288 | 1.17 | 6.6 | 4.1 | 9.2 | 53.2 | 39 | 20 | 16 | 11 | 24 | 54 | 0 | 7 | 1 | 0 | 0 | 2 | 1 | 5.13 |
| SP | Harang, A.Harang, Aaron >> | 29 | 2007 | R | 52 | 2 | 2 | 0 | 0 | 7.56 | .390 | 1.80 | 11.3 | 5.6 | 3.4 | 8.1 | 10 | 7 | 7 | 2 | 5 | 3 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 7.75 |
| SP | Burnett, A.Burnett, A.J. >> | 25 | 2002 | R | 57 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Verlander, J.Verlander, Justin >> | 26 | 2009 | R | 43 | 3 | 0 | 1 | 0 | 9.82 | .421 | 2.18 | 12.0 | 12.0 | 21.0 | 3.2 | 4 | 4 | 4 | 0 | 4 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.33 |
| SP | Willis, D.Willis, Dontrelle >> | 23 | 2005 | L | 49 | 30 | 0 | 3 | 7 | 9.14 | .373 | 1.71 | 13.3 | 2.3 | 5.3 | 44.1 | 65 | 47 | 45 | 11 | 11 | 26 | 0 | 2 | 4 | 0 | 0 | 3 | 2 | 6.02 |