| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 95 | 33 | 33 | 16 | 9 | 2.90 | .285 | 1.15 | 6.5 | 3.9 | 9.0 | 201.2 | 145 | 67 | 65 | 18 | 87 | 201 | 0 | 0 | 0 | 0 | 20 | 9 | 1 | 3.60 |
| SP | Halladay, R.Halladay, Roy # >> | 28 | 2005 | R | 86 | 33 | 33 | 10 | 14 | 5.21 | .303 | 1.30 | 9.5 | 2.2 | 6.9 | 198.2 | 210 | 120 | 115 | 28 | 48 | 151 | 5 | 0 | 0 | 2 | 13 | 1 | 4 | 4.06 |
| SP | Duchscherer, J.Duchscherer, Justin >> | 31 | 2008 | R | 85 | 32 | 32 | 20 | 5 | 3.36 | .278 | 1.14 | 7.2 | 3.0 | 5.6 | 211.1 | 169 | 82 | 79 | 25 | 71 | 132 | 3 | 0 | 0 | 2 | 21 | 4 | 4 | 4.36 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 100 | 71 | 0 | 5 | 3 | 3.00 | .266 | 1.07 | 6.9 | 2.7 | 11.6 | 69.0 | 53 | 23 | 23 | 9 | 21 | 89 | 0 | 49 | 6 | 0 | 0 | 1 | 1 | 3.07 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 84 | 61 | 0 | 5 | 2 | 2.94 | .276 | 1.11 | 5.5 | 4.6 | 9.1 | 67.1 | 41 | 25 | 22 | 7 | 34 | 68 | 0 | 4 | 2 | 0 | 0 | 2 | 1 | 3.94 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 79 | 37 | 0 | 3 | 1 | 2.49 | .330 | 1.34 | 6.7 | 5.4 | 9.8 | 43.1 | 32 | 14 | 12 | 6 | 26 | 47 | 0 | 1 | 2 | 0 | 0 | 6 | 3 | 4.86 |
| SP | Verlander, J.Verlander, Justin >> | 26 | 2009 | R | 42 | 24 | 0 | 3 | 2 | 2.63 | .300 | 1.26 | 7.2 | 4.2 | 8.2 | 99.1 | 79 | 31 | 29 | 9 | 46 | 90 | 0 | 1 | 0 | 0 | 0 | 3 | 4 | 3.85 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 68 | 29 | 0 | 2 | 0 | 5.40 | .345 | 1.55 | 9.0 | 5.2 | 11.6 | 31.2 | 31 | 19 | 19 | 4 | 18 | 40 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.94 |