| SP | Schmidt, J.Schmidt, Jason † >> | 30 | 2003 | R | 98 | 19 | 19 | 9 | 9 | 3.91 | .288 | 1.17 | 8.1 | 2.4 | 8.9 | 140.1 | 126 | 61 | 61 | 16 | 38 | 139 | 5 | 0 | 0 | 3 | 9 | 6 | 1 | 3.44 |
| SP | Young, C.Young, Chris † >> | 28 | 2007 | R | 82 | 19 | 19 | 8 | 7 | 3.24 | .299 | 1.25 | 7.4 | 4.0 | 7.5 | 116.2 | 95 | 45 | 42 | 13 | 51 | 97 | 1 | 0 | 0 | 0 | 13 | 3 | 5 | 4.18 |
| SP | Buehrle, M.Buehrle, Mark # >> | 22 | 2001 | L | 66 | 18 | 18 | 6 | 9 | 4.94 | .308 | 1.30 | 8.6 | 3.2 | 5.9 | 120.1 | 114 | 66 | 66 | 23 | 42 | 79 | 3 | 0 | 0 | 1 | 7 | 5 | 1 | 5.35 |
| SP | Clement, M.Clement, Matt >> | 28 | 2002 | R | 53 | 18 | 18 | 7 | 7 | 5.64 | .340 | 1.52 | 9.3 | 4.4 | 8.5 | 105.1 | 109 | 68 | 66 | 20 | 51 | 99 | 1 | 0 | 0 | 0 | 9 | 3 | 4 | 5.13 |
| SP | Shields, J.Shields, James >> | 26 | 2007 | R | 52 | 18 | 18 | 6 | 8 | 4.86 | .329 | 1.43 | 9.7 | 3.3 | 7.3 | 107.1 | 115 | 60 | 58 | 20 | 39 | 87 | 0 | 0 | 0 | 0 | 9 | 4 | 4 | 5.01 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 44 | 0 | 3 | 2 | 4.09 | .251 | 0.97 | 6.8 | 2.1 | 10.6 | 61.2 | 46 | 29 | 28 | 10 | 14 | 72 | 0 | 5 | 3 | 0 | 0 | 2 | 0 | 3.56 |
| RP | Politte, C.Politte, Cliff >> | 31 | 2005 | R | 66 | 33 | 0 | 3 | 1 | 6.39 | .359 | 1.65 | 8.4 | 6.4 | 8.1 | 31.0 | 29 | 22 | 22 | 4 | 22 | 28 | 0 | 3 | 1 | 0 | 0 | 1 | 1 | 5.10 |
| RP | Williamson, S.Williamson, Scott >> | 26 | 2002 | R | 50 | 24 | 0 | 1 | 2 | 6.48 | .370 | 1.76 | 9.0 | 6.8 | 9.0 | 25.0 | 25 | 18 | 18 | 5 | 19 | 25 | 0 | 2 | 0 | 0 | 0 | 0 | 3 | 5.88 |
| SP | Beckett, J.Beckett, Josh >> | 27 | 2007 | R | 48 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Verlander, J.Verlander, Justin >> | 26 | 2009 | R | 42 | 4 | 0 | 0 | 0 | 4.70 | .303 | 1.30 | 6.4 | 6.4 | 10.3 | 7.2 | 5 | 4 | 4 | 0 | 5 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.86 |
| SP | Kazmir, S.Kazmir, Scott >> | 24 | 2008 | L | 39 | 11 | 0 | 0 | 1 | 9.37 | .443 | 2.33 | 14.6 | 6.8 | 9.6 | 16.1 | 26 | 23 | 17 | 6 | 12 | 17 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 8.19 |