| SP | Martinez, P.Martinez, Pedro † # >> | 26 | 1997 | R | 95 | 25 | 25 | 17 | 5 | 3.35 | .285 | 1.16 | 7.2 | 3.3 | 10.0 | 204.0 | 163 | 80 | 76 | 24 | 74 | 226 | 9 | 0 | 0 | 2 | 15 | 7 | 3 | 3.50 |
| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 99 | 25 | 25 | 16 | 6 | 3.55 | .299 | 1.25 | 8.1 | 3.2 | 9.4 | 157.1 | 142 | 65 | 62 | 14 | 55 | 164 | 1 | 0 | 0 | 1 | 14 | 4 | 0 | 3.20 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 72 | 24 | 24 | 12 | 11 | 5.13 | .344 | 1.55 | 10.0 | 3.9 | 5.9 | 165.0 | 184 | 98 | 94 | 19 | 72 | 109 | 3 | 0 | 0 | 0 | 13 | 4 | 7 | 4.56 |
| SP | Strasburg, S.Strasburg, Stephen # >> | 24 | 2013 | R | 64 | 24 | 24 | 7 | 11 | 6.02 | .355 | 1.63 | 10.7 | 3.9 | 8.2 | 142.0 | 169 | 97 | 95 | 19 | 62 | 130 | 0 | 0 | 0 | 0 | 7 | 3 | 5 | 4.28 |
| SP | Zimmermann, J.Zimmermann, Jordan # >> | 27 | 2013 | R | 43 | 24 | 24 | 7 | 9 | 5.38 | .341 | 1.54 | 10.5 | 3.4 | 6.8 | 152.1 | 178 | 91 | 91 | 18 | 57 | 115 | 2 | 0 | 0 | 0 | 13 | 1 | 4 | 4.17 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 100 | 63 | 0 | 1 | 2 | 2.44 | .257 | 1.02 | 7.4 | 1.8 | 8.2 | 88.2 | 72 | 28 | 24 | 6 | 18 | 80 | 0 | 5 | 2 | 0 | 0 | 2 | 2 | 2.75 |
| RP | Reardon, J.Reardon, Jeff † >> | 26 | 1981 | R | 87 | 60 | 0 | 7 | 1 | 1.82 | .256 | 1.03 | 5.8 | 3.5 | 4.4 | 89.0 | 57 | 20 | 18 | 5 | 35 | 44 | 0 | 9 | 3 | 0 | 0 | 0 | 1 | 3.92 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 81 | 32 | 0 | 5 | 0 | 2.43 | .310 | 1.35 | 8.5 | 3.8 | 9.3 | 33.1 | 31 | 9 | 9 | 4 | 14 | 34 | 0 | 5 | 2 | 0 | 0 | 0 | 0 | 3.79 |
| RP | Kelley, S.Kelley, Shawn >> | 32 | 2016 | R | 71 | 14 | 0 | 1 | 3 | 4.76 | .333 | 1.41 | 6.5 | 6.5 | 9.8 | 11.1 | 8 | 6 | 6 | 2 | 8 | 12 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 5.64 |
| RP | Hudson, D.Hudson, Daniel >> | 34 | 2021 | R | 63 | 6 | 0 | 1 | 0 | 1.80 | .286 | 1.00 | 7.2 | 1.8 | 10.8 | 5.0 | 4 | 1 | 1 | 1 | 1 | 6 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.40 |
| RP | Rivero, F.Rivero, Felipe >> | 23 | 2015 | L | 46 | 5 | 0 | 0 | 0 | 1.80 | .318 | 1.40 | 10.8 | 1.8 | 5.4 | 5.0 | 6 | 3 | 1 | 1 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.00 |
| RP | Valdez, S.Valdez, Sergio >> | 28 | 1992 | R | 48 | 14 | 0 | 0 | 0 | 4.58 | .354 | 1.58 | 8.5 | 6.4 | 6.9 | 17.2 | 16 | 10 | 9 | 1 | 12 | 13 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 4.53 |
| RP | Embree, A.Embree, Alan >> | 32 | 2002 | L | 37 | 11 | 0 | 0 | 0 | 6.20 | .425 | 2.16 | 12.2 | 7.7 | 8.6 | 20.1 | 27 | 14 | 14 | 0 | 17 | 19 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 3.80 |