| SP | Martinez, P.Martinez, Pedro † >> | 26 | 1997 | R | 95 | 19 | 19 | 10 | 6 | 3.50 | .291 | 1.21 | 8.5 | 2.5 | 9.4 | 154.1 | 145 | 62 | 60 | 16 | 42 | 160 | 8 | 0 | 0 | 2 | 12 | 3 | 4 | 3.15 |
| SP | Scherzer, M.Scherzer, Max † >> | 37 | 2021 | R | 99 | 19 | 19 | 13 | 2 | 3.21 | .286 | 1.18 | 7.3 | 3.4 | 10.1 | 123.1 | 100 | 46 | 44 | 6 | 46 | 138 | 2 | 0 | 0 | 1 | 10 | 2 | 0 | 2.56 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 78 | 18 | 18 | 7 | 9 | 4.68 | .349 | 1.59 | 9.9 | 4.5 | 5.9 | 125.0 | 137 | 69 | 65 | 13 | 62 | 82 | 2 | 0 | 0 | 0 | 8 | 2 | 4 | 4.58 |
| SP | Strasburg, S.Strasburg, Stephen # >> | 24 | 2013 | R | 64 | 18 | 18 | 6 | 7 | 4.17 | .306 | 1.31 | 9.1 | 2.7 | 9.0 | 118.2 | 119 | 56 | 55 | 12 | 36 | 118 | 0 | 0 | 0 | 0 | 11 | 2 | 3 | 3.29 |
| SP | Zimmermann, J.Zimmermann, Jordan >> | 27 | 2013 | R | 49 | 18 | 18 | 10 | 3 | 3.72 | .310 | 1.31 | 9.2 | 2.7 | 6.0 | 125.2 | 128 | 57 | 52 | 9 | 37 | 84 | 0 | 0 | 0 | 0 | 12 | 4 | 3 | 3.58 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 47 | 0 | 1 | 2 | 2.47 | .254 | 1.02 | 7.8 | 1.5 | 9.6 | 65.2 | 56 | 18 | 18 | 5 | 11 | 69 | 0 | 4 | 3 | 0 | 0 | 0 | 2 | 2.38 |
| RP | Reardon, J.Reardon, Jeff >> | 26 | 1981 | R | 89 | 42 | 0 | 6 | 4 | 2.88 | .262 | 1.07 | 6.6 | 3.1 | 6.4 | 56.1 | 41 | 19 | 18 | 2 | 19 | 40 | 0 | 8 | 2 | 0 | 0 | 0 | 1 | 3.05 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 86 | 21 | 0 | 2 | 0 | 2.96 | .305 | 1.27 | 7.5 | 4.1 | 8.6 | 24.1 | 20 | 8 | 8 | 3 | 11 | 23 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 4.21 |
| RP | Kelley, S.Kelley, Shawn >> | 32 | 2016 | R | 67 | 9 | 0 | 0 | 1 | 1.17 | .258 | 0.91 | 5.1 | 3.9 | 6.4 | 7.2 | 4 | 1 | 1 | 0 | 3 | 5 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 3.29 |
| RP | Hudson, D.Hudson, Daniel >> | 34 | 2021 | R | 58 | 4 | 0 | 0 | 1 | 3.86 | .222 | 0.86 | 6.8 | 2.3 | 9.0 | 4.2 | 3 | 2 | 2 | 2 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 8.25 |
| RP | Valdez, S.Valdez, Sergio >> | 28 | 1992 | R | 53 | 5 | 0 | 0 | 0 | 9.64 | .440 | 2.36 | 13.5 | 11.3 | 6.8 | 4.2 | 6 | 5 | 5 | 0 | 5 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 5.25 |
| RP | Rivero, F.Rivero, Felipe >> | 23 | 2015 | L | 48 | 15 | 0 | 1 | 0 | 3.94 | .314 | 1.38 | 7.3 | 5.1 | 5.6 | 16.0 | 13 | 7 | 7 | 2 | 9 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 5.06 |