| SP | Strahm, M.Strahm, Matt >> | 26 | 2018 | L | 82 | 13 | 13 | 0 | 3 | 4.44 | .318 | 1.40 | 7.9 | 4.9 | 10.1 | 24.1 | 21 | 12 | 12 | 4 | 13 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.54 |
| SP | Pivetta, N.Pivetta, Nick >> | 32 | 2025 | R | 62 | 12 | 12 | 3 | 3 | 4.86 | .301 | 1.28 | 8.0 | 3.6 | 9.5 | 70.1 | 62 | 39 | 38 | 10 | 28 | 74 | 0 | 0 | 0 | 0 | 6 | 1 | 0 | 3.99 |
| SP | Pomeranz, D.Pomeranz, Drew >> | 27 | 2016 | L | 67 | 12 | 12 | 6 | 3 | 3.68 | .304 | 1.30 | 7.9 | 3.8 | 9.3 | 71.0 | 62 | 32 | 29 | 9 | 30 | 73 | 0 | 0 | 0 | 0 | 6 | 1 | 6 | 3.90 |
| SP | Darvish, Y.Darvish, Yu >> | 35 | 2022 | R | 64 | 11 | 11 | 4 | 5 | 3.66 | .264 | 1.06 | 6.2 | 3.4 | 10.0 | 64.0 | 44 | 26 | 26 | 8 | 24 | 71 | 0 | 0 | 0 | 0 | 7 | 1 | 1 | 3.58 |
| SP | Paddack, C.Paddack, Chris >> | 23 | 2019 | R | 60 | 11 | 10 | 3 | 3 | 3.62 | .338 | 1.51 | 9.2 | 4.6 | 8.4 | 49.2 | 50 | 20 | 20 | 6 | 25 | 46 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.31 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 98 | 33 | 0 | 3 | 1 | 3.32 | .293 | 1.25 | 7.5 | 3.8 | 10.0 | 43.1 | 36 | 18 | 16 | 4 | 18 | 48 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 3.23 |
| RP | Benoit, J.Benoit, Joaquin >> | 37 | 2014 | R | 92 | 30 | 0 | 2 | 2 | 2.45 | .248 | 0.99 | 6.1 | 2.9 | 8.3 | 40.1 | 27 | 11 | 11 | 2 | 13 | 37 | 0 | 3 | 2 | 0 | 0 | 0 | 1 | 2.78 |
| RP | Lamet, D.Lamet, Dinelson # >> | 27 | 2020 | R | 79 | 25 | 0 | 2 | 5 | 5.47 | .304 | 1.27 | 8.5 | 3.1 | 11.8 | 52.2 | 49 | 32 | 32 | 8 | 18 | 68 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 3.54 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 75 | 27 | 0 | 1 | 1 | 2.18 | .250 | 1.00 | 7.4 | 1.6 | 7.1 | 33.0 | 27 | 9 | 8 | 4 | 6 | 26 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 3.55 |
| RP | Castillo, J.Castillo, Jose >> | 22 | 2018 | L | 67 | 16 | 0 | 2 | 0 | 3.24 | .275 | 1.14 | 6.8 | 3.9 | 10.1 | 16.2 | 12 | 6 | 6 | 3 | 7 | 18 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.50 |
| RP | McCullers, L.McCullers, Lance >> | 21 | 1985 | R | 38 | 17 | 0 | 3 | 1 | 3.86 | .287 | 1.21 | 6.1 | 5.0 | 7.6 | 25.2 | 17 | 11 | 11 | 6 | 14 | 21 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 6.12 |