| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 28 | 28 | 9 | 15 | 3.91 | .306 | 1.29 | 8.3 | 3.3 | 7.1 | 198.0 | 183 | 94 | 86 | 17 | 72 | 157 | 4 | 0 | 0 | 1 | 17 | 7 | 2 | 3.73 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 28 | 28 | 11 | 12 | 4.04 | .282 | 1.16 | 9.0 | 1.5 | 4.5 | 200.1 | 199 | 94 | 90 | 15 | 34 | 101 | 10 | 0 | 0 | 1 | 16 | 3 | 1 | 3.52 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 84 | 27 | 27 | 5 | 9 | 7.75 | .364 | 1.67 | 12.0 | 3.0 | 4.0 | 130.0 | 173 | 116 | 112 | 31 | 44 | 58 | 0 | 0 | 0 | 0 | 6 | 6 | 3 | 6.36 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 27 | 27 | 10 | 12 | 4.67 | .332 | 1.44 | 9.3 | 3.8 | 4.6 | 165.2 | 170 | 89 | 86 | 21 | 69 | 84 | 1 | 0 | 0 | 0 | 13 | 8 | 3 | 5.04 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 27 | 27 | 12 | 10 | 5.19 | .325 | 1.44 | 9.1 | 3.9 | 4.8 | 180.1 | 182 | 106 | 104 | 24 | 77 | 95 | 5 | 0 | 0 | 0 | 12 | 2 | 8 | 4.99 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 55 | 0 | 5 | 3 | 4.98 | .323 | 1.43 | 9.0 | 3.9 | 7.9 | 56.0 | 56 | 31 | 31 | 13 | 24 | 49 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 5.55 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 68 | 36 | 0 | 1 | 2 | 3.34 | .300 | 1.24 | 7.7 | 3.5 | 7.2 | 56.2 | 48 | 23 | 21 | 5 | 22 | 45 | 0 | 4 | 1 | 0 | 0 | 3 | 5 | 3.89 |