| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 34 | 34 | 10 | 17 | 3.96 | .286 | 1.19 | 8.3 | 2.4 | 8.4 | 241.0 | 222 | 112 | 106 | 34 | 65 | 225 | 10 | 0 | 0 | 2 | 20 | 3 | 6 | 3.81 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 32 | 32 | 12 | 17 | 5.45 | .334 | 1.49 | 10.0 | 3.5 | 5.3 | 214.2 | 237 | 132 | 130 | 25 | 83 | 125 | 9 | 0 | 0 | 0 | 11 | 3 | 4 | 4.56 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 32 | 32 | 13 | 12 | 3.72 | .316 | 1.37 | 8.2 | 4.1 | 4.1 | 220.1 | 201 | 100 | 91 | 24 | 100 | 99 | 1 | 0 | 0 | 0 | 19 | 4 | 5 | 4.94 |
| SP | Drysdale, D.Drysdale, Don # >> | 28 | 1964 | R | 58 | 30 | 30 | 11 | 13 | 4.58 | .324 | 1.41 | 9.9 | 2.9 | 4.2 | 210.1 | 230 | 111 | 107 | 24 | 67 | 97 | 10 | 0 | 0 | 1 | 15 | 6 | 3 | 4.60 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 83 | 0 | 4 | 4 | 2.56 | .279 | 1.13 | 6.2 | 4.0 | 8.8 | 130.0 | 89 | 38 | 37 | 9 | 58 | 127 | 0 | 15 | 4 | 0 | 0 | 4 | 0 | 3.38 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 68 | 0 | 2 | 5 | 3.32 | .288 | 1.18 | 7.9 | 2.7 | 7.4 | 84.0 | 74 | 39 | 31 | 9 | 25 | 69 | 0 | 3 | 2 | 0 | 0 | 3 | 0 | 3.75 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 62 | 48 | 0 | 7 | 3 | 2.82 | .275 | 1.10 | 5.7 | 4.4 | 10.1 | 60.2 | 38 | 20 | 19 | 7 | 29 | 67 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 3.83 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 54 | 43 | 0 | 1 | 1 | 3.20 | .252 | 0.98 | 6.1 | 2.7 | 8.4 | 56.1 | 38 | 20 | 20 | 4 | 17 | 52 | 0 | 3 | 1 | 0 | 0 | 2 | 1 | 3.09 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 58 | 16 | 0 | 2 | 5 | 3.58 | .320 | 1.37 | 9.0 | 3.7 | 6.7 | 27.2 | 27 | 12 | 11 | 2 | 11 | 20 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.81 |